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Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

Publication ,  Journal Article
Hayes, MG; Urbanek, M; Ehrmann, DA; Armstrong, LL; Lee, JY; Sisk, R; Karaderi, T; Barber, TM; McCarthy, MI; Franks, S; Lindgren, CM; Welt, CK ...
Published in: Nat Commun
August 18, 2015

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels. Three loci reach genome-wide significance in the case-control meta-analysis, two novel loci mapping to chr 8p23.1 [Corrected] and chr 11p14.1, and a chr 9q22.32 locus previously found in Chinese PCOS. The same chr 11p14.1 SNP, rs11031006, in the region of the follicle-stimulating hormone B polypeptide (FSHB) gene strongly associates with PCOS diagnosis and luteinizing hormone levels. These findings implicate neuroendocrine changes in disease pathogenesis.

Duke Scholars

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 18, 2015

Volume

6

Start / End Page

7502

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Polycystic Ovary Syndrome
  • Middle Aged
  • Humans
  • Genome-Wide Association Study
  • Gene Expression Regulation
  • Female
 

Citation

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Hayes, M. G., Urbanek, M., Ehrmann, D. A., Armstrong, L. L., Lee, J. Y., Sisk, R., … Dunaif, A. (2015). Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun, 6, 7502. https://doi.org/10.1038/ncomms8502
Hayes, M Geoffrey, Margrit Urbanek, David A. Ehrmann, Loren L. Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, et al. “Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Nat Commun 6 (August 18, 2015): 7502. https://doi.org/10.1038/ncomms8502.
Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, et al. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015 Aug 18;6:7502.
Hayes, M. Geoffrey, et al. “Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Nat Commun, vol. 6, Aug. 2015, p. 7502. Pubmed, doi:10.1038/ncomms8502.
Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015 Aug 18;6:7502.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 18, 2015

Volume

6

Start / End Page

7502

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Polycystic Ovary Syndrome
  • Middle Aged
  • Humans
  • Genome-Wide Association Study
  • Gene Expression Regulation
  • Female