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5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq.

Publication ,  Journal Article
Telch, MJ; Beevers, CG; Rosenfield, D; Lee, H-J; Reijntjes, A; Ferrell, RE; Hariri, AR
Published in: World psychiatry : official journal of the World Psychiatric Association (WPA)
June 2015

Exposure to war zone stressors is common, yet only a minority of soldiers experience clinically meaningful disturbance in psychological function. Identification of biomarkers that predict vulnerability to war zone stressors is critical for developing more effective treatment and prevention strategies not only in soldiers but also in civilians who are exposed to trauma. We investigated the role of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype in predicting the emergence of post-traumatic stress disorder (PTSD), depressive and anxiety symptoms as a function of war zone stressors. A prospective cohort of 133 U.S. Army soldiers with no prior history of deployment to a war zone, who were scheduled to deploy to Iraq, was recruited. Multilevel regression models were used to investigate associations between 5-HTTLPR genotype, level of war zone stressors, and reported symptoms of PTSD, depression and anxiety while deployed to Iraq. Level of war zone stressors was associated with symptoms of PTSD, depression and anxiety. Consistent with its effects on stress responsiveness, 5-HTTLPR genotype moderated the relationship between level of war zone stressors and symptoms of emotional disturbance. Specifically, soldiers carrying one or two low functioning alleles (S or LG ) reported heightened symptoms of PTSD, depression and anxiety in response to increased levels of exposure to war zone stressors, relative to soldiers homozygous for the high functioning allele (LA ). These data suggest that 5-HTTLPR genotype moderates individual sensitivity to war zone stressors and the expression of emotional disturbance including PTSD symptoms. Replication of this association along with identification of other genetic moderators of risk can inform the development of biomarkers that can predict relative resilience vs. vulnerability to stress.

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Published In

World psychiatry : official journal of the World Psychiatric Association (WPA)

DOI

EISSN

2051-5545

ISSN

1723-8617

Publication Date

June 2015

Volume

14

Issue

2

Start / End Page

198 / 206

Related Subject Headings

  • Psychiatry
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Telch, M. J., Beevers, C. G., Rosenfield, D., Lee, H.-J., Reijntjes, A., Ferrell, R. E., & Hariri, A. R. (2015). 5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq. World Psychiatry : Official Journal of the World Psychiatric Association (WPA), 14(2), 198–206. https://doi.org/10.1002/wps.20215
Telch, Michael J., Christopher G. Beevers, David Rosenfield, Han-Joo Lee, Albert Reijntjes, Robert E. Ferrell, and Ahmad R. Hariri. “5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq.World Psychiatry : Official Journal of the World Psychiatric Association (WPA) 14, no. 2 (June 2015): 198–206. https://doi.org/10.1002/wps.20215.
Telch MJ, Beevers CG, Rosenfield D, Lee H-J, Reijntjes A, Ferrell RE, et al. 5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq. World psychiatry : official journal of the World Psychiatric Association (WPA). 2015 Jun;14(2):198–206.
Telch, Michael J., et al. “5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq.World Psychiatry : Official Journal of the World Psychiatric Association (WPA), vol. 14, no. 2, June 2015, pp. 198–206. Epmc, doi:10.1002/wps.20215.
Telch MJ, Beevers CG, Rosenfield D, Lee H-J, Reijntjes A, Ferrell RE, Hariri AR. 5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq. World psychiatry : official journal of the World Psychiatric Association (WPA). 2015 Jun;14(2):198–206.
Journal cover image

Published In

World psychiatry : official journal of the World Psychiatric Association (WPA)

DOI

EISSN

2051-5545

ISSN

1723-8617

Publication Date

June 2015

Volume

14

Issue

2

Start / End Page

198 / 206

Related Subject Headings

  • Psychiatry
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1103 Clinical Sciences