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Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial.

Publication ,  Journal Article
Visco, AG; Brubaker, L; Jelovsek, JE; Wilson, TS; Norton, P; Zyczynski, HM; Spino, C; Sirls, L; Nguyen, JN; Rahn, DD; Meikle, SF; Nolen, TL ...
Published in: Female Pelvic Med Reconstr Surg
2016

OBJECTIVES: Medication adherence with urgency urinary incontinence (UUI) treatment is challenging and the best assessment methodology is uncertain. We sought to describe adherence with anticholinergic (AC) versus placebo (P) by comparing pill counts and MEMSCAP event data and to identify factors associated with adherence. METHODS: The randomized controlled AC versus Botox Comparison trial of women with moderate to severe idiopathic UUI included 126 participants initiating AC plus P bladder injection and 121 receiving P pills plus Botox injection. Adherence data on 243 participants (124 AC and 119 P) were calculated by pill count and MEMSCAP data for each 2-month interval during the 6-month study that allowed for dose escalation/drug change. Overall composite adherence estimates were calculated using the average of both methods and weighted by the duration of each 2-month interval. RESULTS: Treatment groups had no significant differences in dosing duration (P = 0.76) or mean adherence (AC, 83.3% [16.8] vs. P, 84.8% [13.8]). Only 53% of women met the dichotomous outcome of more than 80% adherence during all intervals. Correlation between adherence by pill counts versus MEMSCAP decreased over time with pill counts demonstrating higher adherence than MEMSCAP (r = 0.53, 0.50, and 0.36 for each 2-month interval). Lower adherence was associated with higher baseline incontinence severity and better UUI quality of life for the AC group and with current smoking status in both groups. CONCLUSIONS: Adherence using pill counts and MEMSCAP was reasonably correlated and similar in both the AC and P groups. In the AC group, higher baseline incontinence severity and better UUI Quality of Life were associated with decreased adherence. Smokers were less adherent.

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Published In

Female Pelvic Med Reconstr Surg

DOI

EISSN

2154-4212

Publication Date

2016

Volume

22

Issue

1

Start / End Page

24 / 28

Location

United States

Related Subject Headings

  • Urological Agents
  • Urinary Incontinence, Urge
  • Treatment Outcome
  • Solifenacin Succinate
  • Prospective Studies
  • Nortropanes
  • Muscarinic Antagonists
  • Middle Aged
  • Medication Adherence
  • Humans
 

Citation

APA
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ICMJE
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Visco, A. G., Brubaker, L., Jelovsek, J. E., Wilson, T. S., Norton, P., Zyczynski, H. M., … Pelvic Floor Disorders Network, . (2016). Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial. Female Pelvic Med Reconstr Surg, 22(1), 24–28. https://doi.org/10.1097/SPV.0000000000000215
Visco, Anthony G., Linda Brubaker, J Eric Jelovsek, Tracey S. Wilson, Peggy Norton, Halina M. Zyczynski, Cathie Spino, et al. “Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial.Female Pelvic Med Reconstr Surg 22, no. 1 (2016): 24–28. https://doi.org/10.1097/SPV.0000000000000215.
Visco AG, Brubaker L, Jelovsek JE, Wilson TS, Norton P, Zyczynski HM, et al. Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial. Female Pelvic Med Reconstr Surg. 2016;22(1):24–8.
Visco, Anthony G., et al. “Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial.Female Pelvic Med Reconstr Surg, vol. 22, no. 1, 2016, pp. 24–28. Pubmed, doi:10.1097/SPV.0000000000000215.
Visco AG, Brubaker L, Jelovsek JE, Wilson TS, Norton P, Zyczynski HM, Spino C, Sirls L, Nguyen JN, Rahn DD, Meikle SF, Nolen TL, Pelvic Floor Disorders Network. Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial. Female Pelvic Med Reconstr Surg. 2016;22(1):24–28.

Published In

Female Pelvic Med Reconstr Surg

DOI

EISSN

2154-4212

Publication Date

2016

Volume

22

Issue

1

Start / End Page

24 / 28

Location

United States

Related Subject Headings

  • Urological Agents
  • Urinary Incontinence, Urge
  • Treatment Outcome
  • Solifenacin Succinate
  • Prospective Studies
  • Nortropanes
  • Muscarinic Antagonists
  • Middle Aged
  • Medication Adherence
  • Humans