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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies.

Publication ,  Journal Article
Alexander, PB; Wang, X-F
Published in: Front Med
June 2015

Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on bypass track resistance, which involves the activation of alternate signaling molecules by tumor cells to bypass inhibition and maintain signaling output, and consider the problems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.

Duke Scholars

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Published In

Front Med

DOI

EISSN

2095-0225

Publication Date

June 2015

Volume

9

Issue

2

Start / End Page

134 / 138

Location

China

Related Subject Headings

  • Signal Transduction
  • Protein-Tyrosine Kinases
  • Lung Neoplasms
  • Humans
  • Drug Resistance, Neoplasm
  • 1199 Other Medical and Health Sciences
  • 1103 Clinical Sciences
 

Citation

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Alexander, P. B., & Wang, X.-F. (2015). Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies. Front Med, 9(2), 134–138. https://doi.org/10.1007/s11684-015-0396-9
Alexander, Peter B., and Xiao-Fan Wang. “Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies.Front Med 9, no. 2 (June 2015): 134–38. https://doi.org/10.1007/s11684-015-0396-9.
Alexander, Peter B., and Xiao-Fan Wang. “Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies.Front Med, vol. 9, no. 2, June 2015, pp. 134–38. Pubmed, doi:10.1007/s11684-015-0396-9.
Journal cover image

Published In

Front Med

DOI

EISSN

2095-0225

Publication Date

June 2015

Volume

9

Issue

2

Start / End Page

134 / 138

Location

China

Related Subject Headings

  • Signal Transduction
  • Protein-Tyrosine Kinases
  • Lung Neoplasms
  • Humans
  • Drug Resistance, Neoplasm
  • 1199 Other Medical and Health Sciences
  • 1103 Clinical Sciences