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A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.

Publication ,  Journal Article
Scult, MA; Trampush, JW; Zheng, F; Conley, ED; Lencz, T; Malhotra, AK; Dickinson, D; Weinberger, DR; Hariri, AR
Published in: Journal of cognitive neuroscience
September 2015

Here we provide novel convergent evidence across three independent cohorts of healthy adults (n = 531), demonstrating that a common polymorphism in the gene encoding the α2 subunit of neuronal voltage-gated type II sodium channels (SCN2A) predicts human general cognitive ability or "g." Using meta-analysis, we demonstrate that the minor T allele of a common polymorphism (rs10174400) in SCN2A is associated with significantly higher "g" independent of gender and age. We further demonstrate using resting-state fMRI data from our discovery cohort (n = 236) that this genetic advantage may be mediated by increased capacity for information processing between the dorsolateral PFC and dorsal ACC, which support higher cognitive functions. Collectively, these findings fill a gap in our understanding of the genetics of general cognitive ability and highlight a specific neural mechanism through which a common polymorphism shapes interindividual variation in "g."

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Published In

Journal of cognitive neuroscience

DOI

EISSN

1530-8898

ISSN

0898-929X

Publication Date

September 2015

Volume

27

Issue

9

Start / End Page

1766 / 1774

Related Subject Headings

  • Young Adult
  • Rest
  • Polymorphism, Genetic
  • Neuropsychological Tests
  • Neural Pathways
  • NAV1.2 Voltage-Gated Sodium Channel
  • Male
  • Magnetic Resonance Imaging
  • Individuality
  • Humans
 

Citation

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Scult, M. A., Trampush, J. W., Zheng, F., Conley, E. D., Lencz, T., Malhotra, A. K., … Hariri, A. R. (2015). A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology. Journal of Cognitive Neuroscience, 27(9), 1766–1774. https://doi.org/10.1162/jocn_a_00826
Scult, Matthew A., Joey W. Trampush, Fengyu Zheng, Emily Drabant Conley, Todd Lencz, Anil K. Malhotra, Dwight Dickinson, Daniel R. Weinberger, and Ahmad R. Hariri. “A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.Journal of Cognitive Neuroscience 27, no. 9 (September 2015): 1766–74. https://doi.org/10.1162/jocn_a_00826.
Scult MA, Trampush JW, Zheng F, Conley ED, Lencz T, Malhotra AK, et al. A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology. Journal of cognitive neuroscience. 2015 Sep;27(9):1766–74.
Scult, Matthew A., et al. “A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.Journal of Cognitive Neuroscience, vol. 27, no. 9, Sept. 2015, pp. 1766–74. Epmc, doi:10.1162/jocn_a_00826.
Scult MA, Trampush JW, Zheng F, Conley ED, Lencz T, Malhotra AK, Dickinson D, Weinberger DR, Hariri AR. A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology. Journal of cognitive neuroscience. 2015 Sep;27(9):1766–1774.
Journal cover image

Published In

Journal of cognitive neuroscience

DOI

EISSN

1530-8898

ISSN

0898-929X

Publication Date

September 2015

Volume

27

Issue

9

Start / End Page

1766 / 1774

Related Subject Headings

  • Young Adult
  • Rest
  • Polymorphism, Genetic
  • Neuropsychological Tests
  • Neural Pathways
  • NAV1.2 Voltage-Gated Sodium Channel
  • Male
  • Magnetic Resonance Imaging
  • Individuality
  • Humans