A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.

Published

Journal Article

Here we provide novel convergent evidence across three independent cohorts of healthy adults (n = 531), demonstrating that a common polymorphism in the gene encoding the α2 subunit of neuronal voltage-gated type II sodium channels (SCN2A) predicts human general cognitive ability or "g." Using meta-analysis, we demonstrate that the minor T allele of a common polymorphism (rs10174400) in SCN2A is associated with significantly higher "g" independent of gender and age. We further demonstrate using resting-state fMRI data from our discovery cohort (n = 236) that this genetic advantage may be mediated by increased capacity for information processing between the dorsolateral PFC and dorsal ACC, which support higher cognitive functions. Collectively, these findings fill a gap in our understanding of the genetics of general cognitive ability and highlight a specific neural mechanism through which a common polymorphism shapes interindividual variation in "g."

Full Text

Duke Authors

Cited Authors

  • Scult, MA; Trampush, JW; Zheng, F; Conley, ED; Lencz, T; Malhotra, AK; Dickinson, D; Weinberger, DR; Hariri, AR

Published Date

  • September 2015

Published In

Volume / Issue

  • 27 / 9

Start / End Page

  • 1766 - 1774

PubMed ID

  • 25961639

Pubmed Central ID

  • 25961639

Electronic International Standard Serial Number (EISSN)

  • 1530-8898

International Standard Serial Number (ISSN)

  • 0898-929X

Digital Object Identifier (DOI)

  • 10.1162/jocn_a_00826

Language

  • eng