A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.

Journal Article (Journal Article)

Here we provide novel convergent evidence across three independent cohorts of healthy adults (n = 531), demonstrating that a common polymorphism in the gene encoding the α2 subunit of neuronal voltage-gated type II sodium channels (SCN2A) predicts human general cognitive ability or "g." Using meta-analysis, we demonstrate that the minor T allele of a common polymorphism (rs10174400) in SCN2A is associated with significantly higher "g" independent of gender and age. We further demonstrate using resting-state fMRI data from our discovery cohort (n = 236) that this genetic advantage may be mediated by increased capacity for information processing between the dorsolateral PFC and dorsal ACC, which support higher cognitive functions. Collectively, these findings fill a gap in our understanding of the genetics of general cognitive ability and highlight a specific neural mechanism through which a common polymorphism shapes interindividual variation in "g."

Full Text

Duke Authors

Cited Authors

  • Scult, MA; Trampush, JW; Zheng, F; Conley, ED; Lencz, T; Malhotra, AK; Dickinson, D; Weinberger, DR; Hariri, AR

Published Date

  • September 2015

Published In

Volume / Issue

  • 27 / 9

Start / End Page

  • 1766 - 1774

PubMed ID

  • 25961639

Pubmed Central ID

  • PMC4692714

Electronic International Standard Serial Number (EISSN)

  • 1530-8898

International Standard Serial Number (ISSN)

  • 0898-929X

Digital Object Identifier (DOI)

  • 10.1162/jocn_a_00826

Language

  • eng