Finding translation in stress research.

Journal Article (Journal Article)

In our ongoing efforts to advance understanding of human diseases, translational research across rodents and humans on stress-related mental disorders stands out as a field that is producing discoveries that illuminate mechanisms of risk and pathophysiology at a brisk rate. Here we offer a Perspective on how a productive translational research dialog between preclinical models and clinical studies of these disorders is being powered by an ever-developing appreciation of the shared neural circuits and genetic architecture that moderate the response to stress across species. Working from these deep foundations, we discuss the approaches, both traditional and innovative, that have the potential to deliver a new generation of risk biomarkers and therapeutic strategies for stress-related disorders.

Full Text

Duke Authors

Cited Authors

  • Hariri, AR; Holmes, A

Published Date

  • October 2015

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 1347 - 1352

PubMed ID

  • 26404709

Pubmed Central ID

  • 26404709

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn.4111


  • eng