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Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.

Publication ,  Journal Article
Zhang, B; Wu, J; Jiao, Y; Bock, C; Dai, M; Chen, B; Chao, N; Zhang, W; Zhuang, Y
Published in: J Immunol
November 1, 2015

Dendritic epidermal T cells (DETCs) are generated exclusively in the fetal thymus and maintained in the skin epithelium throughout postnatal life of the mouse. DETCs have restricted antigenic specificity as a result of their exclusive usage of a canonical TCR. Although the importance of the TCR in DETC development has been well established, the exact role of TCR signaling in DETC homeostasis and function remains incompletely defined. In this study, we investigated TCR signaling in fully matured DETCs by lineage-restricted deletion of the Lat gene, an essential signaling molecule downstream of the TCR. We found that Lat deletion impaired TCR-dependent cytokine gene activation and the ability of DETCs to undergo proliferative expansion. However, linker for activation of T cells-deficient DETCs were able to maintain long-term population homeostasis, although with a reduced proliferation rate. Mice with Lat deletion in DETCs exhibited delayed wound healing accompanied by impaired clonal expansion within the wound area. Our study revealed differential requirements for TCR signaling in homeostatic maintenance of DETCs and in their effector function during wound healing.

Duke Scholars

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

November 1, 2015

Volume

195

Issue

9

Start / End Page

4282 / 4291

Location

United States

Related Subject Headings

  • Wound Healing
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Phosphoproteins
  • Microscopy, Confocal
  • Mice, Transgenic
  • Mice, Knockout
  • Membrane Proteins
  • Luminescent Proteins
 

Citation

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Zhang, B., Wu, J., Jiao, Y., Bock, C., Dai, M., Chen, B., … Zhuang, Y. (2015). Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol, 195(9), 4282–4291. https://doi.org/10.4049/jimmunol.1501220
Zhang, Baojun, Jianxuan Wu, Yiqun Jiao, Cheryl Bock, Meifang Dai, Benny Chen, Nelson Chao, Weiguo Zhang, and Yuan Zhuang. “Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.J Immunol 195, no. 9 (November 1, 2015): 4282–91. https://doi.org/10.4049/jimmunol.1501220.
Zhang B, Wu J, Jiao Y, Bock C, Dai M, Chen B, et al. Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol. 2015 Nov 1;195(9):4282–91.
Zhang, Baojun, et al. “Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.J Immunol, vol. 195, no. 9, Nov. 2015, pp. 4282–91. Pubmed, doi:10.4049/jimmunol.1501220.
Zhang B, Wu J, Jiao Y, Bock C, Dai M, Chen B, Chao N, Zhang W, Zhuang Y. Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol. 2015 Nov 1;195(9):4282–4291.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

November 1, 2015

Volume

195

Issue

9

Start / End Page

4282 / 4291

Location

United States

Related Subject Headings

  • Wound Healing
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Phosphoproteins
  • Microscopy, Confocal
  • Mice, Transgenic
  • Mice, Knockout
  • Membrane Proteins
  • Luminescent Proteins