Drug delivery and therapeutic impact of extended-release acetylsalicylic acid.
Journal Article (Journal Article;Review)
Current treatment guidelines recommend once-daily, low-dose acetylsalicylic acid (ASA; aspirin) for secondary prevention of cardiovascular events. However, the anti-thrombotic benefits of traditional ASA formulations may not extend over a 24-h period, especially in patients at high risk for a recurrent cardiovascular event. A next-generation, extended-release ASA formulation (ER-ASA) has been developed to provide 24-h anti-thrombotic coverage with once-daily dosing. The pharmacokinetics of ER-ASA indicates slower absorption and prolonged ASA release versus immediate-release ASA, with a favorable safety profile. ER-ASA minimizes systemic ASA absorption and provides sustained antiplatelet effects over a 24-h period.
Full Text
Duke Authors
Cited Authors
- Bliden, KP; Patrick, J; Pennell, AT; Tantry, US; Gurbel, PA
Published Date
- January 2016
Published In
Volume / Issue
- 12 / 1
Start / End Page
- 45 - 58
PubMed ID
- 26356085
Electronic International Standard Serial Number (EISSN)
- 1744-8298
Digital Object Identifier (DOI)
- 10.2217/fca.15.60
Language
- eng
Conference Location
- England