A structural framework for interpretation of four-electrode microimpedance spectra in cardiac tissue.

Conference Paper

Renewed interest in the four-electrode method for identification of passive electrical properties in cardiac tissue has been sparked by a recognition that measurements made with sensors in close proximity are frequency dependent. Therefore, resolution of four-electrode microimpedance spectra (4EMS) may provide an opportunity for routine identification of passive electrical properties for the interstitial and intracellular compartments using only interstitial access. The present study documents a structural framework in which the tissue resistivity (ρt) and reactivity (xt) that comprise spectra are computed using interstitial and intracellular microimpedance distributions that account for differences in compartment size, anisotropic electrical properties in each compartment and electrode separations. We used this framework to consider 4EMS development with relatively wide (d=1 mm) and fine (d=250 μm) electrode separations and sensors oriented along myocyte axes, across myocyte axes and intermediate between those axes.

Full Text

Duke Authors

Cited Authors

  • Pollard, AE; Barr, RC

Published Date

  • January 2014

Published In

  • Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference

Volume / Issue

  • 2014 /

Start / End Page

  • 6467 - 6470

PubMed ID

  • 25571477

Pubmed Central ID

  • PMC4288478

Electronic International Standard Serial Number (EISSN)

  • 2694-0604

International Standard Serial Number (ISSN)

  • 2375-7477

Digital Object Identifier (DOI)

  • 10.1109/embc.2014.6945109