Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies.

Published

Journal Article

Influenza B virus is a human pathogen responsible for significant health and economic burden. Research into this pathogen has been limited by the lack of reporter viruses. Here we describe the development of both a replication-competent fluorescent influenza B reporter virus and bioluminescent influenza B reporter virus. Furthermore, we demonstrate these reporter viruses can be used to quickly monitor viral growth and permit the rapid screening of antiviral compounds and neutralizing antibodies.

Full Text

Duke Authors

Cited Authors

  • Fulton, BO; Palese, P; Heaton, NS

Published Date

  • December 2015

Published In

Volume / Issue

  • 89 / 23

Start / End Page

  • 12226 - 12231

PubMed ID

  • 26401044

Pubmed Central ID

  • 26401044

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.02164-15

Language

  • eng

Conference Location

  • United States