Superoxide dismutases: anti- versus pro- oxidants?


Journal Article

The family of superoxide dismutases (SODs) are well known for their antioxidant actions exerted by catalyzing the conversion of O(2)(·-) into H(2)O(2) plus oxygen. The importance of this action is revealed by the multiple phenotypic deficits exhibited by a variety of organisms that have been made to lack one or more of the SODs. Never the less there have been reports of deleterious consequences caused by overproduction of SOD. Several explanations have been proposed for these counter intuitive effects; one of which is that elevated SOD causes increased formation of H(2)O(2). The reasons for dismissing this explanation are explored.

Full Text

Cited Authors

  • Fridovich, I

Published Date

  • February 2011

Published In

Volume / Issue

  • 11 / 2

Start / End Page

  • 175 - 177

PubMed ID

  • 21182471

Pubmed Central ID

  • 21182471

Electronic International Standard Serial Number (EISSN)

  • 1875-5992

Digital Object Identifier (DOI)

  • 10.2174/187152011795255966


  • eng

Conference Location

  • Netherlands