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Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy.

Publication ,  Journal Article
Bashir, MR; Zhong, X; Nickel, MD; Fananapazir, G; Kannengiesser, SAR; Kiefer, B; Dale, BM
Published in: AJR Am J Roentgenol
February 2015

OBJECTIVE. The purpose of this study is to prospectively compare hybrid and complex chemical shift-based MRI fat quantification methods against MR spectroscopy (MRS) for the measurement of hepatic steatosis. SUBJECTS AND METHODS. Forty-two subjects (18 men and 24 women; mean ± SD age, 52.8 ± 14 years) were prospectively enrolled and imaged at 3 T with a chemical shift-based MRI sequence and a single-voxel MRS sequence, each in one breath-hold. Proton density fat fraction and rate constant (R2*) using both single- and dual-R2* hybrid fitting methods, as well as proton density fat fraction and R2* maps using a complex fitting method, were generated. A single radiologist colocalized volumes of interest on the proton density fat fraction and R2* maps according to the spectroscopy measurement voxel. Agreement among the three MRI methods and the MRS proton density fat fraction values was assessed using linear regression, intraclass correlation coefficient (ICC), and Bland-Altman analysis. RESULTS. Correlation between the MRI and MRS measures of proton density fat fraction was excellent. Linear regression coefficients ranged from 0.98 to 1.01, and intercepts ranged from -1.12% to 0.49%. Agreement measured by ICC was also excellent (0.99 for all three methods). Bland-Altman analysis showed excellent agreement, with mean differences of -1.0% to 0.6% (SD, 1.3-1.6%). CONCLUSION. The described MRI-based liver proton density fat fraction measures are clinically feasible and accurate. The validation of proton density fat fraction quantification methods is an important step toward wide availability and acceptance of the MRI-based measurement of proton density fat fraction as an accurate and generalizable biomarker.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

February 2015

Volume

204

Issue

2

Start / End Page

297 / 306

Location

United States

Related Subject Headings

  • Young Adult
  • Protons
  • Prospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bashir, M. R., Zhong, X., Nickel, M. D., Fananapazir, G., Kannengiesser, S. A. R., Kiefer, B., & Dale, B. M. (2015). Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy. AJR Am J Roentgenol, 204(2), 297–306. https://doi.org/10.2214/AJR.14.12457
Bashir, Mustafa R., Xiaodong Zhong, Marcel D. Nickel, Ghaneh Fananapazir, Stephan A. R. Kannengiesser, Berthold Kiefer, and Brian M. Dale. “Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy.AJR Am J Roentgenol 204, no. 2 (February 2015): 297–306. https://doi.org/10.2214/AJR.14.12457.
Bashir MR, Zhong X, Nickel MD, Fananapazir G, Kannengiesser SAR, Kiefer B, et al. Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy. AJR Am J Roentgenol. 2015 Feb;204(2):297–306.
Bashir, Mustafa R., et al. “Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy.AJR Am J Roentgenol, vol. 204, no. 2, Feb. 2015, pp. 297–306. Pubmed, doi:10.2214/AJR.14.12457.
Bashir MR, Zhong X, Nickel MD, Fananapazir G, Kannengiesser SAR, Kiefer B, Dale BM. Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy. AJR Am J Roentgenol. 2015 Feb;204(2):297–306.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

February 2015

Volume

204

Issue

2

Start / End Page

297 / 306

Location

United States

Related Subject Headings

  • Young Adult
  • Protons
  • Prospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Female