An unexpected alliance between stress responses to drive oncogenesis.

Journal Article

XBP1 is a well-characterized regulator of the unfolding protein response that is activated in response to unfolded or misfolded proteins or nutrient deprivation. The conventional wisdom is that XBP1 is activated to coordinate the unfolded protein response and promote cellular survival under stresses. A recent study provides intriguing evidence that, in triple-negative breast cancer, XBP1 plays a major role in promoting oncogenesis and cancer stem cell properties. Unexpectedly, XBP1 accomplishes this by recruiting hypoxia-inducible factor 1α and activating oncogenic transcriptional programs. This study reveals a surprising hierarchy and alliance between two stress regulators with distinct transcriptional outputs to promote an aggressive oncogenic state.

Full Text

Duke Authors

Cited Authors

  • Keenan, MM; Ding, C-KC; Chi, J-T

Published Date

  • November 6, 2014

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 471 -

PubMed ID

  • 25927911

Pubmed Central ID

  • 25927911

Electronic International Standard Serial Number (EISSN)

  • 1465-542X

Digital Object Identifier (DOI)

  • 10.1186/s13058-014-0471-1


  • eng

Conference Location

  • England