Spatial Moran models, II: cancer initiation in spatially structured tissue.

Published

Journal Article

We study the accumulation and spread of advantageous mutations in a spatial stochastic model of cancer initiation on a lattice. The parameters of this general model can be tuned to study a variety of cancer types and genetic progression pathways. This investigation contributes to an understanding of how the selective advantage of cancer cells together with the rates of mutations driving cancer, impact the process and timing of carcinogenesis. These results can be used to give insights into tumor heterogeneity and the "cancer field effect," the observation that a malignancy is often surrounded by cells that have undergone premalignant transformation.

Full Text

Duke Authors

Cited Authors

  • Durrett, R; Foo, J; Leder, K

Published Date

  • April 2016

Published In

Volume / Issue

  • 72 / 5

Start / End Page

  • 1369 - 1400

PubMed ID

  • 26126947

Pubmed Central ID

  • 26126947

Electronic International Standard Serial Number (EISSN)

  • 1432-1416

International Standard Serial Number (ISSN)

  • 0303-6812

Digital Object Identifier (DOI)

  • 10.1007/s00285-015-0912-1

Language

  • eng