Spatial Moran models, II: cancer initiation in spatially structured tissue.
Publication
, Journal Article
Durrett, R; Foo, J; Leder, K
Published in: Journal of mathematical biology
April 2016
We study the accumulation and spread of advantageous mutations in a spatial stochastic model of cancer initiation on a lattice. The parameters of this general model can be tuned to study a variety of cancer types and genetic progression pathways. This investigation contributes to an understanding of how the selective advantage of cancer cells together with the rates of mutations driving cancer, impact the process and timing of carcinogenesis. These results can be used to give insights into tumor heterogeneity and the "cancer field effect," the observation that a malignancy is often surrounded by cells that have undergone premalignant transformation.
Duke Scholars
Published In
Journal of mathematical biology
DOI
EISSN
1432-1416
ISSN
0303-6812
Publication Date
April 2016
Volume
72
Issue
5
Start / End Page
1369 / 1400
Related Subject Headings
- Time Factors
- Stochastic Processes
- Neoplasms
- Mutation
- Models, Genetic
- Models, Biological
- Mathematical Concepts
- Humans
- Computer Simulation
- Bioinformatics
Citation
APA
Chicago
ICMJE
MLA
NLM
Durrett, R., Foo, J., & Leder, K. (2016). Spatial Moran models, II: cancer initiation in spatially structured tissue. Journal of Mathematical Biology, 72(5), 1369–1400. https://doi.org/10.1007/s00285-015-0912-1
Durrett, R., J. Foo, and K. Leder. “Spatial Moran models, II: cancer initiation in spatially structured tissue.” Journal of Mathematical Biology 72, no. 5 (April 2016): 1369–1400. https://doi.org/10.1007/s00285-015-0912-1.
Durrett R, Foo J, Leder K. Spatial Moran models, II: cancer initiation in spatially structured tissue. Journal of mathematical biology. 2016 Apr;72(5):1369–400.
Durrett, R., et al. “Spatial Moran models, II: cancer initiation in spatially structured tissue.” Journal of Mathematical Biology, vol. 72, no. 5, Apr. 2016, pp. 1369–400. Epmc, doi:10.1007/s00285-015-0912-1.
Durrett R, Foo J, Leder K. Spatial Moran models, II: cancer initiation in spatially structured tissue. Journal of mathematical biology. 2016 Apr;72(5):1369–1400.
Published In
Journal of mathematical biology
DOI
EISSN
1432-1416
ISSN
0303-6812
Publication Date
April 2016
Volume
72
Issue
5
Start / End Page
1369 / 1400
Related Subject Headings
- Time Factors
- Stochastic Processes
- Neoplasms
- Mutation
- Models, Genetic
- Models, Biological
- Mathematical Concepts
- Humans
- Computer Simulation
- Bioinformatics