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Spatial Moran models, II: cancer initiation in spatially structured tissue.

Publication ,  Journal Article
Durrett, R; Foo, J; Leder, K
Published in: Journal of mathematical biology
April 2016

We study the accumulation and spread of advantageous mutations in a spatial stochastic model of cancer initiation on a lattice. The parameters of this general model can be tuned to study a variety of cancer types and genetic progression pathways. This investigation contributes to an understanding of how the selective advantage of cancer cells together with the rates of mutations driving cancer, impact the process and timing of carcinogenesis. These results can be used to give insights into tumor heterogeneity and the "cancer field effect," the observation that a malignancy is often surrounded by cells that have undergone premalignant transformation.

Duke Scholars

Published In

Journal of mathematical biology

DOI

EISSN

1432-1416

ISSN

0303-6812

Publication Date

April 2016

Volume

72

Issue

5

Start / End Page

1369 / 1400

Related Subject Headings

  • Time Factors
  • Stochastic Processes
  • Neoplasms
  • Mutation
  • Models, Genetic
  • Models, Biological
  • Mathematical Concepts
  • Humans
  • Computer Simulation
  • Bioinformatics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Durrett, R., Foo, J., & Leder, K. (2016). Spatial Moran models, II: cancer initiation in spatially structured tissue. Journal of Mathematical Biology, 72(5), 1369–1400. https://doi.org/10.1007/s00285-015-0912-1
Durrett, R., J. Foo, and K. Leder. “Spatial Moran models, II: cancer initiation in spatially structured tissue.Journal of Mathematical Biology 72, no. 5 (April 2016): 1369–1400. https://doi.org/10.1007/s00285-015-0912-1.
Durrett R, Foo J, Leder K. Spatial Moran models, II: cancer initiation in spatially structured tissue. Journal of mathematical biology. 2016 Apr;72(5):1369–400.
Durrett, R., et al. “Spatial Moran models, II: cancer initiation in spatially structured tissue.Journal of Mathematical Biology, vol. 72, no. 5, Apr. 2016, pp. 1369–400. Epmc, doi:10.1007/s00285-015-0912-1.
Durrett R, Foo J, Leder K. Spatial Moran models, II: cancer initiation in spatially structured tissue. Journal of mathematical biology. 2016 Apr;72(5):1369–1400.
Journal cover image

Published In

Journal of mathematical biology

DOI

EISSN

1432-1416

ISSN

0303-6812

Publication Date

April 2016

Volume

72

Issue

5

Start / End Page

1369 / 1400

Related Subject Headings

  • Time Factors
  • Stochastic Processes
  • Neoplasms
  • Mutation
  • Models, Genetic
  • Models, Biological
  • Mathematical Concepts
  • Humans
  • Computer Simulation
  • Bioinformatics