The Angiotensin AT<inf>2</inf> Receptor: From Enigma to Therapeutic Target
© 2015 Elsevier Inc. Since its discovery, 25 years ago, the angiotensin AT < inf > 2 < /inf > receptor (AT < inf > 2 < /inf > R) has puzzled the scientific community because of its distinct -localization, regulation, signaling pathways, and biological effects separating it clearly from the classical features of the renin-angiotensin system (RAS) mediated by the angiotensin AT < inf > 1 < /inf > receptor. Intensive research over the years has revealed major characteristics of the AT < inf > 2 < /inf > R as a modulatory player involved in antiproliferation, anti-inflammation, natriuresis, neuroregeneration, and apoptosis, that is, -biological programs that can counterbalance pathological processes and enable recovery from disease. The AT < inf > 2 < /inf > R has thus mutated from an "-enigmatic" receptor to a significant member of the "protective arm" of the RAS. The recent development of novel, small molecule- and peptide-derived AT < inf > 2 < /inf > R agonists offers a therapeutic potential in humans with a variety of clinical indications.
Unger, T; Steckelings, UM; Dzau, VJ
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