Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen. II. Surface markers.


Journal Article

Fifteen of 16 lymphoma-derived cell lines and the Faji and P3HR1 cell lines were characterized with regard to certain surface markers, particularly immunoglobulins, complement receptors, Epstein-Barr virus (EBV) receptors, and Fc receptors. Ten lines positive for EBV nuclear antigen (EB-pos) were stained weakly or not at all by antihuman immunoglobulin fluorescein isothiocyanate conjugates, whereas EBV nuclear antigen negative (EB-neg) cell lines stained brightly. EB-pos lines frequently manifested Fc receptors, particularly for 7S antibody, whereas EB-neg lines did not. Receptors for the C3b component of complement and for EBV, which correlated significantly with each other, were expressed to a much lesser extent by EB-neg lines than by EB-pos lines. These findings are pertinent to an understanding of the infrequent association of this virus with American undifferentiated lymphomas of the Burkitt's and non-Burkitt's types.

Full Text

Cited Authors

  • Magrath, IT; Freeman, CB; Pizzo, P; Gadek, J; Jaffe, E; Santaella, M; Hammer, C; Frank, M; Reaman, G; Novikovs, L

Published Date

  • March 1, 1980

Published In

Volume / Issue

  • 64 / 3

Start / End Page

  • 477 - 483

PubMed ID

  • 6243722

Pubmed Central ID

  • 6243722

International Standard Serial Number (ISSN)

  • 0027-8874


  • eng

Conference Location

  • United States