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Renal autotransplants in sheep: investigation of renal function and renovascular hypertension.

Publication ,  Journal Article
McDougall, JG; Coghlan, JP; Denton, DA; Fei, DT; Hammond, TG; Hardy, KJ; Potocnik, SJ; Scoggins, BA; Wright, RD
Published in: Clin Exp Pharmacol Physiol
1981

1. A novel surgical preparation of sheep with a cervical renal autotransplant has been developed. 2. Glomerular filtration rate and effective renal plasma flow were 25.1 +/- 1.0 ml/min and 208 +/- 10 ml/min respectively (n = 26). 3. The responses to water load and deprivation, to AVP injection, to Na depletion and intravenous hypertonic saline load show the kidneys responded in an appropriate physiological manner. 4. Constriction of the carotid-renal artery to reduce mean renal arterial pressure to 23 +/- 4 mmHg (n = 4) resulted in an increase in systemic mean arterial pressure from 70 +/- 4 mmHg to 75 +/- 4 mmHg within 5 min. Systemic blood pressure further increased to 110 +/- 7 mmHg with 2 h of constriction, when renal arterial pressure had increased to 45 +/- 2 mmHg.

Duke Scholars

Published In

Clin Exp Pharmacol Physiol

DOI

ISSN

0305-1870

Publication Date

1981

Volume

8

Issue

5

Start / End Page

497 / 501

Location

Australia

Related Subject Headings

  • Water Deprivation
  • Transplantation, Autologous
  • Sodium Chloride
  • Sheep
  • Renal Circulation
  • Renal Artery Obstruction
  • Physiology
  • Kidney Transplantation
  • Kidney
  • Hypertension, Renovascular
 

Citation

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McDougall, J. G., Coghlan, J. P., Denton, D. A., Fei, D. T., Hammond, T. G., Hardy, K. J., … Wright, R. D. (1981). Renal autotransplants in sheep: investigation of renal function and renovascular hypertension. Clin Exp Pharmacol Physiol, 8(5), 497–501. https://doi.org/10.1111/j.1440-1681.1981.tb00756.x
McDougall, J. G., J. P. Coghlan, D. A. Denton, D. T. Fei, T. G. Hammond, K. J. Hardy, S. J. Potocnik, B. A. Scoggins, and R. D. Wright. “Renal autotransplants in sheep: investigation of renal function and renovascular hypertension.Clin Exp Pharmacol Physiol 8, no. 5 (1981): 497–501. https://doi.org/10.1111/j.1440-1681.1981.tb00756.x.
McDougall JG, Coghlan JP, Denton DA, Fei DT, Hammond TG, Hardy KJ, et al. Renal autotransplants in sheep: investigation of renal function and renovascular hypertension. Clin Exp Pharmacol Physiol. 1981;8(5):497–501.
McDougall, J. G., et al. “Renal autotransplants in sheep: investigation of renal function and renovascular hypertension.Clin Exp Pharmacol Physiol, vol. 8, no. 5, 1981, pp. 497–501. Pubmed, doi:10.1111/j.1440-1681.1981.tb00756.x.
McDougall JG, Coghlan JP, Denton DA, Fei DT, Hammond TG, Hardy KJ, Potocnik SJ, Scoggins BA, Wright RD. Renal autotransplants in sheep: investigation of renal function and renovascular hypertension. Clin Exp Pharmacol Physiol. 1981;8(5):497–501.
Journal cover image

Published In

Clin Exp Pharmacol Physiol

DOI

ISSN

0305-1870

Publication Date

1981

Volume

8

Issue

5

Start / End Page

497 / 501

Location

Australia

Related Subject Headings

  • Water Deprivation
  • Transplantation, Autologous
  • Sodium Chloride
  • Sheep
  • Renal Circulation
  • Renal Artery Obstruction
  • Physiology
  • Kidney Transplantation
  • Kidney
  • Hypertension, Renovascular