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Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.

Publication ,  Journal Article
Keeshan, K; He, Y; Wouters, BJ; Shestova, O; Xu, L; Sai, H; Rodriguez, CG; Maillard, I; Tobias, JW; Valk, P; Carroll, M; Aster, JC; Delwel, R ...
Published in: Cancer Cell
November 2006
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Tribbles homolog 2 (Trib2) was identified as a downregulated transcript in leukemic cells undergoing growth arrest. To investigate the effects of Trib2 in hematopoietic progenitors, mice were reconstituted with hematopoietic stem cells retrovirally expressing Trib2. Trib2-transduced bone marrow cells exhibited a growth advantage ex vivo and readily established factor-dependent cell lines. In vivo, Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). In mechanistic studies, we found that Trib2 associated with and inhibited C/EBPalpha. Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha.

Duke Scholars

Yiping He
Author Yiping He Pathology
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Published In

Cancer Cell

DOI

10.1016/j.ccr.2006.09.012

ISSN

1535-6108

Publication Date

November 2006

Volume

10

Issue

5

Start / End Page

401 / 411

Location

United States

Related Subject Headings

  • Transplantation Chimera
  • Survival Rate
  • RNA Interference
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Oncogenes
  • Mice, Inbred C57BL
  • Mice
  • Leukemia, Myeloid, Acute
  • Intracellular Signaling Peptides and Proteins
 

Citation

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Keeshan, K., He, Y., Wouters, B. J., Shestova, O., Xu, L., Sai, H., … Pear, W. S. (2006). Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell, 10(5), 401–411. https://doi.org/10.1016/j.ccr.2006.09.012
Keeshan, Karen, Yiping He, Bas J. Wouters, Olga Shestova, Lanwei Xu, Hong Sai, Carlos G. Rodriguez, et al. “Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.” Cancer Cell 10, no. 5 (November 2006): 401–11. https://doi.org/10.1016/j.ccr.2006.09.012.
Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, et al. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell. 2006 Nov;10(5):401–11.
Keeshan, Karen, et al. “Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.” Cancer Cell, vol. 10, no. 5, Nov. 2006, pp. 401–11. Pubmed, doi:10.1016/j.ccr.2006.09.012.
Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell. 2006 Nov;10(5):401–411.
Journal cover image

Published In

Cancer Cell

DOI

10.1016/j.ccr.2006.09.012

ISSN

1535-6108

Publication Date

November 2006

Volume

10

Issue

5

Start / End Page

401 / 411

Location

United States

Related Subject Headings

  • Transplantation Chimera
  • Survival Rate
  • RNA Interference
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Oncogenes
  • Mice, Inbred C57BL
  • Mice
  • Leukemia, Myeloid, Acute
  • Intracellular Signaling Peptides and Proteins