One shall become two: Separation of the esophagus and trachea from the common foregut tube.

Journal Article (Journal Article;Review)

The alimentary and respiratory organ systems arise from a common endodermal origin, the anterior foregut tube. Formation of the esophagus from the dorsal region and the trachea from the ventral region of the foregut primordium occurs by means of a poorly understood compartmentalization process. Disruption of this process can result in severe birth defects, such as esophageal atresia and tracheo-esphageal fistula (EA/TEF), in which the lumina of the trachea and esophagus remain connected. Here we summarize the signaling networks known to be necessary for regulating dorsoventral patterning within the common foregut tube and cellular behaviors that may occur during normal foregut compartmentalization. We propose that dorsoventral patterning serves to establish a lateral region of the foregut tube that is capable of undergoing specialized cellular rearrangements, culminating in compartmentalization. We review established as well as new rodent models that may be useful in addressing this hypothesis. Finally, we discuss new experimental models that could help elucidate the mechanism behind foregut compartmentalization. An integrated approach to future foregut morphogenesis research will allow for a better understanding of this complex process.

Full Text

Duke Authors

Cited Authors

  • Billmyre, KK; Hutson, M; Klingensmith, J

Published Date

  • March 2015

Published In

Volume / Issue

  • 244 / 3

Start / End Page

  • 277 - 288

PubMed ID

  • 25329576

Pubmed Central ID

  • PMC4778253

Electronic International Standard Serial Number (EISSN)

  • 1097-0177

Digital Object Identifier (DOI)

  • 10.1002/dvdy.24219


  • eng

Conference Location

  • United States