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Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations.

Publication ,  Journal Article
Park, HS; Do, YS; Park, KB; Kim, K-H; Woo, SY; Jung, S-H; Kim, D-I; Kim, YW; Hyun, D; Cho, SK; Choo, IW
Published in: Eur Radiol
May 2016

OBJECTIVES: To evaluate clinical outcomes and their predictors in patients with venous malformation (VM) treated with foam sodium tetradecyl sulfate (STS) sclerotherapy. METHODS: We retrospectively evaluated clinical outcomes of foam STS sclerotherapy in 86 patients with 91 VMs to assess reduction in pain and mass after treatment. Univariate and multivariate analysis was performed to determine possible predictors of clinical outcome with foam STS sclerotherapy. RESULTS: A positive response of 49.5% in pain reduction and 52.7% in mass reduction was observed. The numerical rating scale (NRS) score improved from 4.36 ± 2.64 to 1.74 ± 1.57, and VM mass volume decreased to 41.7 ± 35.52% of the initial size. On multivariate analysis, a high baseline NRS score (odds ratio: 1.12, 95% confidence interval: 1.09-1.15) and VM location in the trunk versus the head and neck (odds ratio: 1.30, 95% confidence interval: 1.00-1.69) were positive predictors of pain improvement. Minor complications occurred in 11 (12.1%) patients and recurrence in 12 (13.2%) patients. CONCLUSIONS: Foam STS sclerotherapy is an effective treatment in venous malformation, with low complication risk. A high baseline NRS score and location in the trunk versus the head and neck were positive predictors in improvement of pain. KEY POINTS: • Foam STS sclerotherapy is effective in VM, with low risk of complications. • Relief of pain tends to be dramatic in patients with severe pain. • Location of VM is a predictor of pain improvement. • The presence of a draining vein does not affect foam sclerotherapy.

Duke Scholars

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

May 2016

Volume

26

Issue

5

Start / End Page

1301 / 1310

Location

Germany

Related Subject Headings

  • Young Adult
  • Vascular Malformations
  • Treatment Outcome
  • Sodium Tetradecyl Sulfate
  • Sclerotherapy
  • Sclerosing Solutions
  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
 

Citation

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Park, H. S., Do, Y. S., Park, K. B., Kim, K.-H., Woo, S. Y., Jung, S.-H., … Choo, I. W. (2016). Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations. Eur Radiol, 26(5), 1301–1310. https://doi.org/10.1007/s00330-015-3931-9
Park, Hong Suk, Young Soo Do, Kwang Bo Park, Keon-Ha Kim, Sook Young Woo, Sin-Ho Jung, Dong-Ik Kim, et al. “Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations.Eur Radiol 26, no. 5 (May 2016): 1301–10. https://doi.org/10.1007/s00330-015-3931-9.
Park HS, Do YS, Park KB, Kim K-H, Woo SY, Jung S-H, et al. Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations. Eur Radiol. 2016 May;26(5):1301–10.
Park, Hong Suk, et al. “Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations.Eur Radiol, vol. 26, no. 5, May 2016, pp. 1301–10. Pubmed, doi:10.1007/s00330-015-3931-9.
Park HS, Do YS, Park KB, Kim K-H, Woo SY, Jung S-H, Kim D-I, Kim YW, Hyun D, Cho SK, Choo IW. Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations. Eur Radiol. 2016 May;26(5):1301–1310.
Journal cover image

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

May 2016

Volume

26

Issue

5

Start / End Page

1301 / 1310

Location

Germany

Related Subject Headings

  • Young Adult
  • Vascular Malformations
  • Treatment Outcome
  • Sodium Tetradecyl Sulfate
  • Sclerotherapy
  • Sclerosing Solutions
  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male