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Subcentimeter hypervascular nodule with typical imaging findings of hepatocellular carcinoma in patients with history of hepatocellular carcinoma: natural course on serial gadoxetic acid-enhanced MRI and diffusion-weighted imaging.

Publication ,  Journal Article
Song, KD; Kim, SH; Lim, HK; Jung, S-H; Sohn, I; Kim, HS
Published in: Eur Radiol
September 2015

OBJECTIVES: To evaluate the natural course of subcentimeter hypervascular nodules at high risk for developing into hepatocellular carcinomas (SHNHR) using serial magnetic resonance imaging (MRI) in patients with a history of hepatocellular carcinoma (HCC). METHODS: An SHNHR was defined as a subcentimeter hypervascular nodule having typical imaging findings of HCC on gadoxetic acid-enhanced MRI and diffusion-weighted imaging. We included 39 patients with 46 SHNHRs (mean size ± standard deviation, 6.1 ± 1.6 mm; range, 3.2 - 9.0 mm). Overt HCC was defined as pathology proven HCC or a nodule larger than 1 cm with typical imaging findings of HCC. The cumulative rate and the independent predictive factors for progression to overt HCC were evaluated. RESULTS: The median follow-up period was 139 days (range, 64 - 392 days). The cumulative progression rate to overt HCC at 3, 6, 9, and 12 months was 13.9%, 61.7%, 83.2%, and 89.9%. The initial size of SHNHR was a significant predictor of progression to overt HCC, with an optimal cut-off value of 5.5 mm. CONCLUSION: The progression rate of SHNHR to overt HCC within 12 months was high (89.9%) in patients with history of HCC. The initial size of SHNHR was an important predictor for progression to overt HCC. KEY POINTS: • Most SHNHRs (89.9%) progressed to overt HCCs within 12 months. • Initial size was an important predictor for progression to overt HCCs. • The optimal cut-off value for initial nodule size was 5.5 mm.

Duke Scholars

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

September 2015

Volume

25

Issue

9

Start / End Page

2789 / 2796

Location

Germany

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Liver
  • Image Enhancement
  • Humans
  • Gadolinium DTPA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Song, K. D., Kim, S. H., Lim, H. K., Jung, S.-H., Sohn, I., & Kim, H. S. (2015). Subcentimeter hypervascular nodule with typical imaging findings of hepatocellular carcinoma in patients with history of hepatocellular carcinoma: natural course on serial gadoxetic acid-enhanced MRI and diffusion-weighted imaging. Eur Radiol, 25(9), 2789–2796. https://doi.org/10.1007/s00330-015-3680-9
Song, Kyoung Doo, Seong Hyun Kim, Hyo Keun Lim, Sin-Ho Jung, Insuk Sohn, and Hyung Sik Kim. “Subcentimeter hypervascular nodule with typical imaging findings of hepatocellular carcinoma in patients with history of hepatocellular carcinoma: natural course on serial gadoxetic acid-enhanced MRI and diffusion-weighted imaging.Eur Radiol 25, no. 9 (September 2015): 2789–96. https://doi.org/10.1007/s00330-015-3680-9.
Journal cover image

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

September 2015

Volume

25

Issue

9

Start / End Page

2789 / 2796

Location

Germany

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Liver
  • Image Enhancement
  • Humans
  • Gadolinium DTPA