Vertebrate Reproduction.

Journal Article (Review;Journal Article)

Vertebrate reproduction requires a myriad of precisely orchestrated events-in particular, the maternal production of oocytes, the paternal production of sperm, successful fertilization, and initiation of early embryonic cell divisions. These processes are governed by a host of signaling pathways. Protein kinase and phosphatase signaling pathways involving Mos, CDK1, RSK, and PP2A regulate meiosis during maturation of the oocyte. Steroid signals-specifically testosterone-regulate spermatogenesis, as does signaling by G-protein-coupled hormone receptors. Finally, calcium signaling is essential for both sperm motility and fertilization. Altogether, this signaling symphony ensures the production of viable offspring, offering a chance of genetic immortality.

Full Text

Duke Authors

Cited Authors

  • Kornbluth, S; Fissore, R

Published Date

  • October 2015

Published In

Volume / Issue

  • 7 / 10

Start / End Page

  • a006064 -

PubMed ID

  • 26430215

Pubmed Central ID

  • PMC4588066

Electronic International Standard Serial Number (EISSN)

  • 1943-0264

International Standard Serial Number (ISSN)

  • 1943-0264

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a006064


  • eng