The complex interplay between metabolism and apoptosis
© 2014 Springer Science+Business Media New York. All rights are reserved. Energy balance is essential for cells to function properly and proliferate. Sufficient nutrient quantities are required for energy and the synthesis of building blocks of cellular structures such as lipid membranes, proteins, and nucleic acids. In contrast, nutrient excess can increase ER stress and reactive oxygen species, leading to cellular damage and apoptosis. In this chapter, we detail three important aspects of the interplay between metabolism and apoptosis: the mechanisms by which metabolic imbalances regulate major signaling effectors in apoptosis, how metabolism itself can be controlled by apoptotic proteins, and the major disease states affected when perturbations in metabolism modulate apoptosis.
Lindblom, K; Kornbluth, S
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