Cell adhesion in epidermal development and barrier formation.

Journal Article (Review)

Cell-cell adhesions are necessary for structural integrity and barrier formation of the epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of individual cell-cell junctions and their composite proteins in regulating epidermal development and function. In addition to individual adhesive functions, we will discuss emerging ideas on mechanosensation/transduction of junctions in the epidermis, noncanonical roles for adhesion proteins, and crosstalk/interdependencies between the junctional systems. These studies have revealed that cell adhesion proteins are connected to many aspects of tissue physiology including growth control, differentiation, and inflammation.

Full Text

Duke Authors

Cited Authors

  • Sumigray, KD; Lechler, T

Published Date

  • January 2015

Published In

Volume / Issue

  • 112 /

Start / End Page

  • 383 - 414

PubMed ID

  • 25733147

Electronic International Standard Serial Number (EISSN)

  • 1557-8933

International Standard Serial Number (ISSN)

  • 0070-2153

Digital Object Identifier (DOI)

  • 10.1016/bs.ctdb.2014.11.027

Language

  • eng