Cell adhesion in epidermal development and barrier formation.

Journal Article (Journal Article;Review)

Cell-cell adhesions are necessary for structural integrity and barrier formation of the epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of individual cell-cell junctions and their composite proteins in regulating epidermal development and function. In addition to individual adhesive functions, we will discuss emerging ideas on mechanosensation/transduction of junctions in the epidermis, noncanonical roles for adhesion proteins, and crosstalk/interdependencies between the junctional systems. These studies have revealed that cell adhesion proteins are connected to many aspects of tissue physiology including growth control, differentiation, and inflammation.

Full Text

Duke Authors

Cited Authors

  • Sumigray, KD; Lechler, T

Published Date

  • 2015

Published In

Volume / Issue

  • 112 /

Start / End Page

  • 383 - 414

PubMed ID

  • 25733147

Pubmed Central ID

  • PMC4737682

Electronic International Standard Serial Number (EISSN)

  • 1557-8933

Digital Object Identifier (DOI)

  • 10.1016/bs.ctdb.2014.11.027


  • eng

Conference Location

  • United States