Causes of treatment failure with antiepileptic drugs vary over time.

Journal Article (Journal Article)

The V.A. Epilepsy Cooperative Study Group evaluated monotherapy with carbamazepine, phenobarbital, phenytoin, and primidone in a total of 622 patients with previously untreated partial seizures. In the 24 months following onset of treatment, 223 patients failed treatment. Analysis of these failures reveals that the majority occurred during the first 6 months with equal contributions to failure from systemic toxicity, neurotoxicity, and seizures. The contribution of systemic toxicity to failure was significantly less in the next 18 months. An increase in the contribution of seizures to failure was seen in this latter period.

Full Text

Duke Authors

Cited Authors

  • Homan, RW; Miller, B

Published Date

  • October 1, 1987

Published In

Volume / Issue

  • 37 / 10

Start / End Page

  • 1620 - 1623

PubMed ID

  • 3658167

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.37.10.1620


  • eng

Conference Location

  • United States