A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults
Published
Journal Article
The design for the comparative evaluation of the efficacy and toxicity of phenobarbital, phenytoin, primidone, and carbamazepine is outlined. A double-blind prospective study of a sufficient number of patients can determine the optimum drug to use initially for partial and generalized tonic-clonic seizures in adults. The rationale for methods defines the major parameters that should be addressed in order to determine optimum drug for longterm seizure therapy. Major problems in the function of such a project include aspects of sample size attainment, screening/recruitment, non-drug-related losses, and adjustments to the ongoing protocol. The design, with modifications, can be used to study other antiepileptic drugs and other types of seizures. © 1983 American Academy of Neurology.
Duke Authors
Cited Authors
- Mattson, RH; Cramer, JA; Escueta, AVD; Smith, DB; Collins, JF; Browne, TR; Crill, WE; Homan, RW; Mayersdorf, A; McCutchen, CB; McNamara, JO; Rosenthal, NP; Treiman, DM; Wilder, BJ; Williamson, PD; Young, LM
Published Date
- January 1, 1983
Published In
Volume / Issue
- 33 / 3
Start / End Page
- 14 - 25
Electronic International Standard Serial Number (EISSN)
- 1526-632X
International Standard Serial Number (ISSN)
- 0028-3878
Citation Source
- Scopus