A method of quantification for the evaluation of antiepileptic drug therapy


Journal Article

The design of clinical trials of antiepileptic drugs should include explicit methods for numeric quantification of seizures and side effects. Rating scales were developed to assess frequency and severity of seizures (partial and generalized tonic-clonic), systemic toxicity, and neurotoxicity. These scales are combined to form a single composite rating that reflects the overall effect of the drug on the patient. The rating system can be adapted to compare efficacy and toxicity of any antiepileptic drugs, for any types of seizures. © 1983 American Academy of Neurology.

Duke Authors

Cited Authors

  • Cramer, JA; Smith, DB; Mattson, RH; Escueta, AVD; Collins, JF; Browne, TR; Crill, WE; Homan, RW; Mayersdorf, A; McCutchen, CB; McNamara, JO; Rosenthal, NP; Treiman, DM; Wilder, BJ; Williamson, PD

Published Date

  • January 1, 1983

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 26 - 37

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

International Standard Serial Number (ISSN)

  • 0028-3878

Citation Source

  • Scopus