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Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

Publication ,  Journal Article
Robey, RB; Weisz, J; Kuemmerle, NB; Salzberg, AC; Berg, A; Brown, DG; Kubik, L; Palorini, R; Al-Mulla, F; Al-Temaimi, R; Colacci, A; Raju, J ...
Published in: Carcinogenesis
June 2015

Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions of environmentally relevant low-dose chemical mixtures and the fact that exposures can influence multiple cancer-associated endpoints over varying timescales. Of these endpoints, dysregulated metabolism is one of the most common and recognizable features of cancer, but its specific roles in exposure-associated cancer development remain poorly understood. Most studies have focused on discrete aspects of cancer metabolism and have incompletely considered both its dynamic integrated nature and the complex controlling influences of substrate availability, external trophic signals and environmental conditions. Emerging high throughput approaches to environmental risk assessment also do not directly address the metabolic causes or consequences of changes in gene expression. As such, there is a compelling need to establish common or complementary frameworks for further exploration that experimentally and conceptually consider the gestalt of cancer metabolism and its causal relationships to both carcinogenesis and the development of other cancer hallmarks. A literature review to identify environmentally relevant exposures unambiguously linked to both cancer development and dysregulated metabolism suggests major gaps in our understanding of exposure-associated carcinogenesis and metabolic reprogramming. Although limited evidence exists to support primary causal roles for metabolism in carcinogenesis, the universality of altered cancer metabolism underscores its fundamental biological importance, and multiple pleiomorphic, even dichotomous, roles for metabolism in promoting, antagonizing or otherwise enabling the development and selection of cancer are suggested.

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Published In

Carcinogenesis

DOI

EISSN

1460-2180

ISSN

0143-3334

Publication Date

June 2015

Volume

36 Suppl 1

Start / End Page

S203 / S231

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Environmental Exposure
  • Carcinogens, Environmental
  • Carcinogenesis
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Robey, R. B., Weisz, J., Kuemmerle, N. B., Salzberg, A. C., Berg, A., Brown, D. G., … Ryan, E. P. (2015). Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis, 36 Suppl 1, S203–S231. https://doi.org/10.1093/carcin/bgv037
Robey, R Brooks, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur Berg, Dustin G. Brown, Laura Kubik, et al. “Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Carcinogenesis 36 Suppl 1 (June 2015): S203–31. https://doi.org/10.1093/carcin/bgv037.
Robey RB, Weisz J, Kuemmerle NB, Salzberg AC, Berg A, Brown DG, et al. Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis. 2015 Jun;36 Suppl 1:S203–31.
Robey, R. Brooks, et al. “Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Carcinogenesis, vol. 36 Suppl 1, June 2015, pp. S203–31. Epmc, doi:10.1093/carcin/bgv037.
Robey RB, Weisz J, Kuemmerle NB, Salzberg AC, Berg A, Brown DG, Kubik L, Palorini R, Al-Mulla F, Al-Temaimi R, Colacci A, Mondello C, Raju J, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Hamid RA, Williams GP, Lowe L, Meyer J, Martin FL, Bisson WH, Chiaradonna F, Ryan EP. Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis. 2015 Jun;36 Suppl 1:S203–S231.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

ISSN

0143-3334

Publication Date

June 2015

Volume

36 Suppl 1

Start / End Page

S203 / S231

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Environmental Exposure
  • Carcinogens, Environmental
  • Carcinogenesis
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis