Pregnancy after treatment for cervical cancer precursor lesions in a retrospective matched cohort.

Journal Article (Journal Article)

OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort study. SETTING: Kaiser Permanente Northwest (KPNW), an integrated healthcare delivery system in Oregon and Washington. PATIENTS: Women 14 to 53 years old with KPNW enrollment during the period 1998 through 2009. MAIN OUTCOME MEASURE: Pregnancy after exposure or index date. Pregnancy was defined using a validated algorithm and electronic medical records data. RESULTS: We observed 570 pregnancies following cervical treatment in 4,137 women, 1,533 pregnancies following a diagnostic procedure in 13,767 women, and 7,436 pregnancies in a frequency-matched sample of 81,435 women unexposed to treatment or diagnostic procedures. After adjusting for age and contraceptive use, we observed a higher rate of pregnancies in the treatment group compared to unexposed women (hazard ratio (HR) = 1.42, 95% confidence interval (CI): 1.30-1.55), but no difference in pregnancy rates between the treatment and diagnostic procedure groups (HR = 1.03, 95% CI: 0.93-1.13). CONCLUSIONS: No adverse effects of cervical procedures on subsequent rates of pregnancy were observed in this cohort with up to twelve years of follow-up time.

Full Text

Duke Authors

Cited Authors

  • Naleway, AL; Weinmann, S; Krishnarajah, G; Arondekar, B; Fernandez, J; Swamy, G; Myers, E

Published Date

  • 2015

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • e0117525 -

PubMed ID

  • 25671561

Pubmed Central ID

  • PMC4324989

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0117525


  • eng

Conference Location

  • United States