The spectrum of fungi that infects humans.

Journal Article (Journal Article;Review)

Few among the millions of fungal species fulfill four basic conditions necessary to infect humans: high temperature tolerance, ability to invade the human host, lysis and absorption of human tissue, and resistance to the human immune system. In previously healthy individuals, invasive fungal disease is rare because animals' sophisticated immune systems evolved in constant response to fungal challenges. In contrast, fungal diseases occur frequently in immunocompromised patients. Paradoxically, successes of modern medicine have put increasing numbers of patients at risk for invasive fungal infections. Uncontrolled HIV infection additionally makes millions vulnerable to lethal fungal diseases. A concerted scientific and social effort is needed to meet these challenges.

Full Text

Duke Authors

Cited Authors

  • Köhler, JR; Casadevall, A; Perfect, J

Published Date

  • November 3, 2014

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • a019273 -

PubMed ID

  • 25367975

Pubmed Central ID

  • PMC4292074

Electronic International Standard Serial Number (EISSN)

  • 2157-1422

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a019273


  • eng

Conference Location

  • United States