Nivolumab: Immunotherapy in Malignant Melanoma.

Journal Article (Journal Article)


Although patients diagnosed with melanoma that is confined to the skin have a five-year survival rate of 98%, this number drops to 16% with widely metastatic disease. Melanoma rates have been steadily increasing since the 1970s, but cytotoxic chemotherapy generally prolongs survival by about four months. Nivolumab is an effective immunotherapy agent.


This article discusses the use of nivolumab for metastatic melanoma.


Clinical trial and early postmarketing data were reviewed.


In clinical trials, patients with advanced melanoma experienced partial sustained responses to nivolumab, a new targeted immunotherapy agent, for more than one year. Nivolumab helps the immune system mobilize lymphocytes that have been inactivated by melanoma cells, enhancing the body's ability to recognize the cancer as abnormal. Compared to conventional chemotherapy, nivolumab has been shown to greatly improve survival in widespread, inoperable malignant melanoma. Oncology nurses will administer, monitor, and educate patients about nivolumab.

Full Text

Duke Authors

Cited Authors

  • Bayless, H; Schneider, S

Published Date

  • August 2015

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 430 - 432

PubMed ID

  • 26207707

Electronic International Standard Serial Number (EISSN)

  • 1538-067X

International Standard Serial Number (ISSN)

  • 1092-1095

Digital Object Identifier (DOI)

  • 10.1188/15.cjon.430-432


  • eng