Oral Manifestations of Chronic Graft-v-Host Disease


Journal Article

Sixty patients were studied 180 to 500 days after allogeneic marrow transplantation to determine if late oral abnormalities were associated with the presence of chronic graft-v-host disease (GVHD). Lip and intraoral mucosal surfaces were evaluated for color, keratinization, atrophy, and erythema. Subjective complaints of oral pain and xerostomia were also recorded. Abnormalities were scored on a scale of 0 to 3 and tested for association with GVHD by χ2 test. Oral manifestations most strongly associated with chronic GVHD included atrophy and erythema or lichenoid lesions of the buccal and labial mucosa and oral pain. Oral manifestations resembled several naturally occurring autoimmune disorders. Recognition of these changes can aid in the clinical diagnosis and assessment of established chronic GVHD. © 1984, American Medical Association. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Schubert, MM; Sullivan, KM; Morton, TH; Izutsu, KT; Peterson, DE; Flournoy, N; Truelove, EL; Sale, GE; Buckner, CD; Storb, R; Thomas, ED

Published Date

  • January 1, 1984

Published In

Volume / Issue

  • 144 / 8

Start / End Page

  • 1591 - 1595

Electronic International Standard Serial Number (EISSN)

  • 1538-3679

International Standard Serial Number (ISSN)

  • 0003-9926

Digital Object Identifier (DOI)

  • 10.1001/archinte.1984.00350200087014

Citation Source

  • Scopus