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Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia.

Publication ,  Journal Article
Mohamed, S; Rosenheck, RA; Lin, H; Swartz, M; McEvoy, J; Stroup, S
Published in: J Nerv Ment Dis
July 2015

No large-scale randomized trial has compared the effect of different second-generation antipsychotic drugs and any first-generation drug on alcohol, drug and nicotine use in patients with schizophrenia. The Clinical Antipsychotic Trial of Intervention Effectiveness study randomly assigned 1432 patients formally diagnosed with schizophrenia to four second-generation antipsychotic drugs (olanzapine, risperidone quetiapine, and ziprasidone) and one first-generation antipsychotic (perphenazine) and followed them for up to 18 months. Secondary outcome data documented cigarettes smoked in the past week and alcohol and drug use severity ratings. At baseline, 61% of patients smoked, 35% used alcohol, and 23% used illicit drugs. Although there were significant effects of time showing reduction in substance use over the 18 months (all p < 0.0001), this study found no evidence that any antipsychotic was robustly superior to any other in a secondary analysis of data on substance use outcomes from a large 18-month randomized schizophrenia trial.

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Published In

J Nerv Ment Dis

DOI

EISSN

1539-736X

Publication Date

July 2015

Volume

203

Issue

7

Start / End Page

486 / 492

Location

United States

Related Subject Headings

  • Young Adult
  • Thiazoles
  • Substance-Related Disorders
  • Smoking Prevention
  • Smoking
  • Schizophrenic Psychology
  • Schizophrenia
  • Risperidone
  • Quetiapine Fumarate
  • Psychiatry
 

Citation

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Mohamed, S., Rosenheck, R. A., Lin, H., Swartz, M., McEvoy, J., & Stroup, S. (2015). Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. J Nerv Ment Dis, 203(7), 486–492. https://doi.org/10.1097/NMD.0000000000000317
Mohamed, Somaia, Robert A. Rosenheck, Haiqun Lin, Marvin Swartz, Joseph McEvoy, and Scott Stroup. “Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia.J Nerv Ment Dis 203, no. 7 (July 2015): 486–92. https://doi.org/10.1097/NMD.0000000000000317.
Mohamed, Somaia, et al. “Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia.J Nerv Ment Dis, vol. 203, no. 7, July 2015, pp. 486–92. Pubmed, doi:10.1097/NMD.0000000000000317.

Published In

J Nerv Ment Dis

DOI

EISSN

1539-736X

Publication Date

July 2015

Volume

203

Issue

7

Start / End Page

486 / 492

Location

United States

Related Subject Headings

  • Young Adult
  • Thiazoles
  • Substance-Related Disorders
  • Smoking Prevention
  • Smoking
  • Schizophrenic Psychology
  • Schizophrenia
  • Risperidone
  • Quetiapine Fumarate
  • Psychiatry