Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.

Journal Article (Journal Article)

Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus and co-localization with cathepsin L, upon classical, but not alternative activation of macrophages. Despite the increased expression of cathepsin L in the nuclei of classically activated macrophages, no cathepsin activity was detected. Since only pro-inflammatory, but not anti-inflammatory stimuli induce increased nucleolar localization of SpiA3G, we propose that SpiA3g translocation into the nucleolus is important in host defense against pathogens.

Full Text

Duke Authors

Cited Authors

  • Konjar, S; Yin, F; Bogyo, M; Turk, B; Kopitar-Jerala, N

Published Date

  • June 3, 2010

Published In

Volume / Issue

  • 584 / 11

Start / End Page

  • 2201 - 2206

PubMed ID

  • 20338168

Pubmed Central ID

  • 20338168

Electronic International Standard Serial Number (EISSN)

  • 1873-3468

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2010.03.031


  • eng

Conference Location

  • England