Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.

Journal Article (Journal Article)

Background.  The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease becoming endemic in the southeast. Methods.  We collected confirmed and probable cases of Lyme disease from 2000 through 2014 from the Virginia Department of Health and North Carolina Department of Public Health and entered them in a geographic information system. We performed spatial and spatiotemporal cluster analyses to characterize Lyme disease expansion. Results.  There was a marked increase in Lyme disease cases in Virginia, particularly from 2007 onwards. Northern Virginia experienced intensification and geographic expansion of Lyme disease cases. The most notable area of expansion was to the southwest along the Appalachian Mountains with development of a new disease cluster in the southern Virginia mountain region. Conclusions.  The geographic distribution of Lyme disease cases significantly expanded in Virginia between 2000 and 2014, particularly southward in the Virginia mountain ranges. If these trends continue, North Carolina can expect autochthonous Lyme disease transmission in its mountain region in the coming years.

Full Text

Duke Authors

Cited Authors

  • Lantos, PM; Nigrovic, LE; Auwaerter, PG; Fowler, VG; Ruffin, F; Brinkerhoff, RJ; Reber, J; Williams, C; Broyhill, J; Pan, WK; Gaines, DN

Published Date

  • December 2015

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • ofv143 -

PubMed ID

  • 26550580

Pubmed Central ID

  • PMC4629694

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofv143


  • eng

Conference Location

  • United States