Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme.
Published
Journal Article
Bioassay-guided fractionation of a petroleum ether extract of the roots of Stellera chamaejasme led to the isolation of seven new (stelleralides D-J, 1-7) and 12 known (8-19) daphnane diterpenoids. The structures and relative configurations of 1-7 were established on the basis of extensive spectroscopic analysis, including HRESIMS and comprehensive NMR techniques. All isolates were evaluated for anti-HIV activity in MT4 cells. All compounds tested, except 2, showed anti-HIV activity, and, especially, five 1α-alkyldaphnane diterpenoids (3, 4, 5, 10, and 11) exhibited extremely potent anti-HIV activity, with EC50 values of 0.06-1.1 nM and selectivity index values of more than 10,000.
Full Text
Duke Authors
Cited Authors
- Yan, M; Lu, Y; Chen, C-H; Zhao, Y; Lee, K-H; Chen, D-F
Published Date
- November 25, 2015
Published In
Volume / Issue
- 78 / 11
Start / End Page
- 2712 - 2718
PubMed ID
- 26562066
Pubmed Central ID
- 26562066
Electronic International Standard Serial Number (EISSN)
- 1520-6025
Digital Object Identifier (DOI)
- 10.1021/acs.jnatprod.5b00660
Language
- eng
Conference Location
- United States