Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme.

Journal Article (Journal Article)

Bioassay-guided fractionation of a petroleum ether extract of the roots of Stellera chamaejasme led to the isolation of seven new (stelleralides D-J, 1-7) and 12 known (8-19) daphnane diterpenoids. The structures and relative configurations of 1-7 were established on the basis of extensive spectroscopic analysis, including HRESIMS and comprehensive NMR techniques. All isolates were evaluated for anti-HIV activity in MT4 cells. All compounds tested, except 2, showed anti-HIV activity, and, especially, five 1α-alkyldaphnane diterpenoids (3, 4, 5, 10, and 11) exhibited extremely potent anti-HIV activity, with EC50 values of 0.06-1.1 nM and selectivity index values of more than 10,000.

Full Text

Duke Authors

Cited Authors

  • Yan, M; Lu, Y; Chen, C-H; Zhao, Y; Lee, K-H; Chen, D-F

Published Date

  • November 25, 2015

Published In

Volume / Issue

  • 78 / 11

Start / End Page

  • 2712 - 2718

PubMed ID

  • 26562066

Pubmed Central ID

  • PMC4774894

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.5b00660


  • eng

Conference Location

  • United States