A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings.


Journal Article

We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test.Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.

Full Text

Duke Authors

Cited Authors

  • Cecchi, M; Moore, DK; Sadowsky, CH; Solomon, PR; Doraiswamy, PM; Smith, CD; Jicha, GA; Budson, AE; Arnold, SE; Fadem, KC

Published Date

  • December 2015

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 387 - 394

PubMed ID

  • 27239520

Pubmed Central ID

  • 27239520

Electronic International Standard Serial Number (EISSN)

  • 2352-8729

International Standard Serial Number (ISSN)

  • 2352-8729

Digital Object Identifier (DOI)

  • 10.1016/j.dadm.2015.08.004


  • eng