Inflammatory biomarkers in osteoarthritis.

Journal Article (Journal Article;Review)

Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite the global burden of OA, diagnostic tests and treatments for the molecular or early subclinical stages are still not available for clinical use. In recent years, there has been a large shift in the understanding of OA as a "wear and tear" disease to an inflammatory disease. This has been demonstrated through various studies using MRI, ultrasound, histochemistry, and biomarkers. It would of great value to be able to readily identify subclinical and/or sub-acute inflammation, particularly in such a way as to be appropriate for a clinical setting. Here we review several types of biomarkers associated with OA in human studies that point to a role of inflammation in OA.

Full Text

Duke Authors

Cited Authors

  • Daghestani, HN; Kraus, VB

Published Date

  • November 2015

Published In

Volume / Issue

  • 23 / 11

Start / End Page

  • 1890 - 1896

PubMed ID

  • 26521734

Pubmed Central ID

  • PMC4630669

Electronic International Standard Serial Number (EISSN)

  • 1522-9653

Digital Object Identifier (DOI)

  • 10.1016/j.joca.2015.02.009


  • eng

Conference Location

  • England