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Virtual Monochromatic Images from Dual-Energy Multidetector CT: Variance in CT Numbers from the Same Lesion between Single-Source Projection-based and Dual-Source Image-based Implementations.

Publication ,  Journal Article
Mileto, A; Barina, A; Marin, D; Stinnett, SS; Roy Choudhury, K; Wilson, JM; Nelson, RC
Published in: Radiology
April 2016

PURPOSE: To determine the variance in virtual monochromatic computed tomography (CT) numbers from the same lesion, comparing the two clinically available dual-energy multidetector CT hardware implementations (single-source projection-based and dual-source image-based), in a phantom-based simulated abdominal environment. MATERIALS AND METHODS: This phantom-based study was exempt from institutional review board oversight. Polyethylene terephthalate spheres (15 and 18 mm) with two iodine-to-saline dilutions (0.8 and 1.2 mg of iodine per millilliter) were serially suspended in a cylindrical polypropylene bottle filled with diluted iodinated contrast material. The bottle was placed into a 36-cm-wide torso-shaped water phantom simulating the abdomen of a medium-sized patient. Dual-energy (80/140 kVp) and single-energy (100 and 120 kVp) scans were obtained with single-source and dual-source multidetector CT implementations. Virtual monochromatic images were reconstructed at energy levels of 40-140 keV (in 10-keV increments) in either the projection-space or image-space domain. A multivariate regression analysis approach was used to investigate the effect of energy level, lesion size, lesion iodine content, and implementation type on measured CT numbers. RESULTS: There were significant differences in the attenuation values measured in the simulated lesions with the single-source projection-based platform and the dual-source image-based implementation (P < .001 for all comparisons). The magnitude of these differences was greatest at lower monochromatic energy levels and at lower iodine concentrations (average difference at 40 keV: 25.7 HU; average difference at 140 keV: 7 HU). The monochromatic energy level and the lesion iodine concentration had a significant effect on the difference in the measured attenuation values between the two implementations, which indicates that the two imaging platforms respond differently to changes in investigated variables (P < .001 for all comparisons). CONCLUSION: There is a statistically significant variance in virtual monochromatic CT numbers from the same lesion examined with single-source projection-based and dual-source image-based implementations. The magnitude of the variance is a function of the selected energy level and the lesion iodine content.

Duke Scholars

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

April 2016

Volume

279

Issue

1

Start / End Page

269 / 277

Location

United States

Related Subject Headings

  • Radiography, Dual-Energy Scanned Projection
  • Radiographic Image Interpretation, Computer-Assisted
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Multidetector Computed Tomography
  • Humans
  • Contrast Media
  • Color
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
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ICMJE
MLA
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Mileto, A., Barina, A., Marin, D., Stinnett, S. S., Roy Choudhury, K., Wilson, J. M., & Nelson, R. C. (2016). Virtual Monochromatic Images from Dual-Energy Multidetector CT: Variance in CT Numbers from the Same Lesion between Single-Source Projection-based and Dual-Source Image-based Implementations. Radiology, 279(1), 269–277. https://doi.org/10.1148/radiol.2015150919
Mileto, Achille, Andrew Barina, Daniele Marin, Sandra S. Stinnett, Kingshuk Roy Choudhury, Joshua M. Wilson, and Rendon C. Nelson. “Virtual Monochromatic Images from Dual-Energy Multidetector CT: Variance in CT Numbers from the Same Lesion between Single-Source Projection-based and Dual-Source Image-based Implementations.Radiology 279, no. 1 (April 2016): 269–77. https://doi.org/10.1148/radiol.2015150919.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

April 2016

Volume

279

Issue

1

Start / End Page

269 / 277

Location

United States

Related Subject Headings

  • Radiography, Dual-Energy Scanned Projection
  • Radiographic Image Interpretation, Computer-Assisted
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Multidetector Computed Tomography
  • Humans
  • Contrast Media
  • Color
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences