Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation.

Published

Journal Article

BACKGROUND: In a randomized trial comparing mitral-valve repair with mitral-valve replacement in patients with severe ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI), survival, or adverse events at 1 year after surgery. However, patients in the repair group had significantly more recurrences of moderate or severe mitral regurgitation. We now report the 2-year outcomes of this trial. METHODS: We randomly assigned 251 patients to mitral-valve repair or replacement. Patients were followed for 2 years, and clinical and echocardiographic outcomes were assessed. RESULTS: Among surviving patients, the mean (±SD) 2-year LVESVI was 52.6±27.7 ml per square meter of body-surface area with mitral-valve repair and 60.6±39.0 ml per square meter with mitral-valve replacement (mean changes from baseline, -9.0 ml per square meter and -6.5 ml per square meter, respectively). Two-year mortality was 19.0% in the repair group and 23.2% in the replacement group (hazard ratio in the repair group, 0.79; 95% confidence interval, 0.46 to 1.35; P=0.39). The rank-based assessment of LVESVI at 2 years (incorporating deaths) showed no significant between-group difference (z score=-1.32, P=0.19). The rate of recurrence of moderate or severe mitral regurgitation over 2 years was higher in the repair group than in the replacement group (58.8% vs. 3.8%, P<0.001). There were no significant between-group differences in rates of serious adverse events and overall readmissions, but patients in the repair group had more serious adverse events related to heart failure (P=0.05) and cardiovascular readmissions (P=0.01). On the Minnesota Living with Heart Failure questionnaire, there was a trend toward greater improvement in the replacement group (P=0.07). CONCLUSIONS: In patients undergoing mitral-valve repair or replacement for severe ischemic mitral regurgitation, we observed no significant between-group difference in left ventricular reverse remodeling or survival at 2 years. Mitral regurgitation recurred more frequently in the repair group, resulting in more heart-failure-related adverse events and cardiovascular admissions. (Funded by the National Institutes of Health and Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT00807040.).

Full Text

Duke Authors

Cited Authors

  • Goldstein, D; Moskowitz, AJ; Gelijns, AC; Ailawadi, G; Parides, MK; Perrault, LP; Hung, JW; Voisine, P; Dagenais, F; Gillinov, AM; Thourani, V; Argenziano, M; Gammie, JS; Mack, M; Demers, P; Atluri, P; Rose, EA; O'Sullivan, K; Williams, DL; Bagiella, E; Michler, RE; Weisel, RD; Miller, MA; Geller, NL; Taddei-Peters, WC; Smith, PK; Moquete, E; Overbey, JR; Kron, IL; O'Gara, PT; Acker, MA; CTSN,

Published Date

  • January 28, 2016

Published In

Volume / Issue

  • 374 / 4

Start / End Page

  • 344 - 353

PubMed ID

  • 26550689

Pubmed Central ID

  • 26550689

Electronic International Standard Serial Number (EISSN)

  • 1533-4406

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1512913

Language

  • eng

Conference Location

  • United States