Actions of thrombin in the interstitium.


Journal Article (Review)

Thrombin is a pleiotropic enzyme best known for its contribution to fibrin formation and platelet aggregation during vascular hemostasis. There is increasing evidence to suggest a role for thrombin in the development of interstitial fibrosis, but interstitial thrombin has not been demonstrated by the direct determination of activity. Rather its presence is inferred by products of thrombin action such as fibrin and activated fibroblasts. This review will focus on possible mechanisms of thrombin formation in the interstitial space, the possible actions of thrombin, processes regulating thrombin activity in the interstitial space, and evidence supporting a role for thrombin in fibrosis.

Full Text

Duke Authors

Cited Authors

  • de Ridder, GG; Lundblad, RL; Pizzo, SV

Published Date

  • January 2016

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 40 - 47

PubMed ID

  • 26564405

Pubmed Central ID

  • 26564405

Electronic International Standard Serial Number (EISSN)

  • 1538-7836

Digital Object Identifier (DOI)

  • 10.1111/jth.13191


  • eng

Conference Location

  • England