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Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid.

Publication ,  Journal Article
Mukherjee, D; Porter, A; Ryan, M; Schwander, S; Chung, KF; Tetley, T; Zhang, J; Georgopoulos, P
Published in: Nanomaterials (Basel, Switzerland)
September 2015

Increasing use of engineered nanomaterials (ENMs) in consumer products may result in widespread human inhalation exposures. Due to their high surface area per unit mass, inhaled ENMs interact with multiple components of the pulmonary system, and these interactions affect their ultimate fate in the body. Modeling of ENM transport and clearance in vivo has traditionally treated tissues as well-mixed compartments, without consideration of nanoscale interaction and transformation mechanisms. ENM agglomeration, dissolution and transport, along with adsorption of biomolecules, such as surfactant lipids and proteins, cause irreversible changes to ENM morphology and surface properties. The model presented in this article quantifies ENM transformation and transport in the alveolar air to liquid interface and estimates eventual alveolar cell dosimetry. This formulation brings together established concepts from colloidal and surface science, physics, and biochemistry to provide a stochastic framework capable of capturing essential in vivo processes in the pulmonary alveolar lining layer. The model has been implemented for in vitro solutions with parameters estimated from relevant published in vitro measurements and has been extended here to in vivo systems simulating human inhalation exposures. Applications are presented for four different ENMs, and relevant kinetic rates are estimated, demonstrating an approach for improving human in vivo pulmonary dosimetry.

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Published In

Nanomaterials (Basel, Switzerland)

DOI

EISSN

2079-4991

ISSN

2079-4991

Publication Date

September 2015

Volume

5

Issue

3

Start / End Page

1223 / 1249

Related Subject Headings

  • 4018 Nanotechnology
  • 4016 Materials engineering
  • 1007 Nanotechnology
  • 0912 Materials Engineering
 

Citation

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Mukherjee, D., Porter, A., Ryan, M., Schwander, S., Chung, K. F., Tetley, T., … Georgopoulos, P. (2015). Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid. Nanomaterials (Basel, Switzerland), 5(3), 1223–1249. https://doi.org/10.3390/nano5031223
Mukherjee, Dwaipayan, Alexandra Porter, Mary Ryan, Stephan Schwander, Kian Fan Chung, Teresa Tetley, Junfeng Zhang, and Panos Georgopoulos. “Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid.Nanomaterials (Basel, Switzerland) 5, no. 3 (September 2015): 1223–49. https://doi.org/10.3390/nano5031223.
Mukherjee D, Porter A, Ryan M, Schwander S, Chung KF, Tetley T, et al. Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid. Nanomaterials (Basel, Switzerland). 2015 Sep;5(3):1223–49.
Mukherjee, Dwaipayan, et al. “Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid.Nanomaterials (Basel, Switzerland), vol. 5, no. 3, Sept. 2015, pp. 1223–49. Epmc, doi:10.3390/nano5031223.
Mukherjee D, Porter A, Ryan M, Schwander S, Chung KF, Tetley T, Zhang J, Georgopoulos P. Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid. Nanomaterials (Basel, Switzerland). 2015 Sep;5(3):1223–1249.

Published In

Nanomaterials (Basel, Switzerland)

DOI

EISSN

2079-4991

ISSN

2079-4991

Publication Date

September 2015

Volume

5

Issue

3

Start / End Page

1223 / 1249

Related Subject Headings

  • 4018 Nanotechnology
  • 4016 Materials engineering
  • 1007 Nanotechnology
  • 0912 Materials Engineering