Design of supramolecular amino acids to template peptide folding.


Journal Article

We describe in this manuscript a new design of supramolecular amino acids (SAAs) for directing peptide folding in organic environments. The incorporated supramolecular motif has a strong driving force to dimerize in a sequence- and orientation-specific manner. By introducing such SAAs into the primary sequence of peptides, the specific and directional dimerization of the supramolecular units should facilitate the folding of the peptides. Our approach may provide a general strategy to program secondary structures in organic media.

Full Text

Cited Authors

  • Mozhdehi, D; Guan, Z

Published Date

  • November 2013

Published In

Volume / Issue

  • 49 / 85

Start / End Page

  • 9950 - 9952

PubMed ID

  • 24036525

Pubmed Central ID

  • 24036525

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/c3cc45419c


  • eng