Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder

Journal Article

© 2015, Springer Science+Business Media New York.Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD.

Full Text

Duke Authors

Cited Authors

  • Richey, JA; Damiano, CR; Sabatino, A; Rittenberg, A; Petty, C; Bizzell, J; Voyvodic, J; Heller, AS; Coffman, MC; Smoski, M; Davidson, RJ; Dichter, GS

Published Date

  • 2015

Published In

Volume / Issue

  • 45 / 11

Start / End Page

  • 3409 - 3423

International Standard Serial Number (ISSN)

  • 0162-3257

Digital Object Identifier (DOI)

  • 10.1007/s10803-015-2359-z