Scholars@Duke

The PsychENCODE project.

Publication ,  Journal Article
PsychENCODE Consortium, ; Akbarian, S; Liu, C; Knowles, JA; Vaccarino, FM; Farnham, PJ; Crawford, GE; Jaffe, AE; Pinto, D; Dracheva, S; Mill, J ...
Published in: Nat Neurosci
December 2015
Published version (DOI) Open Access Copy (Duke) Link to item

Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well as many common variants located primarily in regulatory regions of the genome. Understanding precisely how these variants contribute to disease will require a deeper appreciation for the mechanisms of gene regulation in the developing and adult human brain. The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type–specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems. We are beginning with a focus on autism spectrum disorder, bipolar disorder and schizophrenia, and expect that this knowledge will apply to a wide variety of psychiatric disorders. This paper outlines the motivation and design of PsychENCODE.

Duke Scholars

Gregory E. Crawford
Author Gregory E. Crawford Pediatrics, Medical Genetics
Allison Elizabeth Ashley-Koch
Author Allison Elizabeth Ashley-Koch Medicine, Nephrology
Timothy E Reddy
Author Timothy E Reddy Biostatistics & Bioinformatics, Division of Integrative Geno ...
Gregory Allan Wray
Author Gregory Allan Wray Biology
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Published In

Nat Neurosci

DOI

10.1038/nn.4156

EISSN

1546-1726

Publication Date

December 2015

Volume

18

Issue

12

Start / End Page

1707 / 1712

Location

United States

Related Subject Headings

  • Transcriptome
  • Neurology & Neurosurgery
  • Mental Disorders
  • Humans
  • Genetic Code
  • Epigenesis, Genetic
  • Chromosome Mapping
  • Brain
  • Animals
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
PsychENCODE Consortium, ., Akbarian, S., Liu, C., Knowles, J. A., Vaccarino, F. M., Farnham, P. J., … Sestan, N. (2015). The PsychENCODE project. Nat Neurosci, 18(12), 1707–1712. https://doi.org/10.1038/nn.4156
PsychENCODE Consortium, Nenad, Schahram Akbarian, Chunyu Liu, James A. Knowles, Flora M. Vaccarino, Peggy J. Farnham, Gregory E. Crawford, et al. “The PsychENCODE project.” Nat Neurosci 18, no. 12 (December 2015): 1707–12. https://doi.org/10.1038/nn.4156.
PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, et al. The PsychENCODE project. Nat Neurosci. 2015 Dec;18(12):1707–12.
PsychENCODE Consortium, Nenad, et al. “The PsychENCODE project.” Nat Neurosci, vol. 18, no. 12, Dec. 2015, pp. 1707–12. Pubmed, doi:10.1038/nn.4156.
PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FCP, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CCY, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N. The PsychENCODE project. Nat Neurosci. 2015 Dec;18(12):1707–1712.

Published In

Nat Neurosci

DOI

10.1038/nn.4156

EISSN

1546-1726

Publication Date

December 2015

Volume

18

Issue

12

Start / End Page

1707 / 1712

Location

United States

Related Subject Headings

  • Transcriptome
  • Neurology & Neurosurgery
  • Mental Disorders
  • Humans
  • Genetic Code
  • Epigenesis, Genetic
  • Chromosome Mapping
  • Brain
  • Animals
  • 5202 Biological psychology