Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.

Journal Article (Journal Article)

The relationship between dietary salt intake and the associated risk of hypertension and cardiovascular disease is an important public health concern. In this issue of the JCI, a study by Zhang and associates shows that consumption of a high-sodium diet induces expression of cyclooxygenase-2 (COX-2) in macrophages, resulting in enhanced levels of prostaglandin E2 (PGE2), autocrine activation of the macrophage E-prostanoid 4 (EP4) receptor, and subsequent triggering of parallel pathways in the kidney and in skin that help dispose of excess sodium. The authors found that blockade or genetic elimination of the COX-2/PGE2/EP4 receptor pathway in hematopoietic cells causes salt-sensitive hypertension in mice. These studies illuminate an unexpected central role for the macrophage in coordinating homeostatic responses to dietary salt intake and suggest a complex pathophysiology for hypertension associated with NSAID use.

Full Text

Duke Authors

Cited Authors

  • Stegbauer, J; Coffman, TM

Published Date

  • November 2, 2015

Published In

Volume / Issue

  • 125 / 11

Start / End Page

  • 4008 - 4010

PubMed ID

  • 26495835

Pubmed Central ID

  • PMC4639952

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI84753


  • eng

Conference Location

  • United States