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Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.

Publication ,  Journal Article
Stegbauer, J; Coffman, TM
Published in: J Clin Invest
November 2, 2015

The relationship between dietary salt intake and the associated risk of hypertension and cardiovascular disease is an important public health concern. In this issue of the JCI, a study by Zhang and associates shows that consumption of a high-sodium diet induces expression of cyclooxygenase-2 (COX-2) in macrophages, resulting in enhanced levels of prostaglandin E2 (PGE2), autocrine activation of the macrophage E-prostanoid 4 (EP4) receptor, and subsequent triggering of parallel pathways in the kidney and in skin that help dispose of excess sodium. The authors found that blockade or genetic elimination of the COX-2/PGE2/EP4 receptor pathway in hematopoietic cells causes salt-sensitive hypertension in mice. These studies illuminate an unexpected central role for the macrophage in coordinating homeostatic responses to dietary salt intake and suggest a complex pathophysiology for hypertension associated with NSAID use.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

November 2, 2015

Volume

125

Issue

11

Start / End Page

4008 / 4010

Location

United States

Related Subject Headings

  • Sulfonamides
  • Sodium Chloride, Dietary
  • Pyrazoles
  • Male
  • Macrophages, Peritoneal
  • Immunology
  • Hypertension
  • Female
  • Dinoprostone
  • Cyclooxygenase 2 Inhibitors
 

Citation

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Stegbauer, J., & Coffman, T. M. (2015). Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin. J Clin Invest, 125(11), 4008–4010. https://doi.org/10.1172/JCI84753
Stegbauer, Johannes, and Thomas M. Coffman. “Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.J Clin Invest 125, no. 11 (November 2, 2015): 4008–10. https://doi.org/10.1172/JCI84753.
Stegbauer J, Coffman TM. Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin. J Clin Invest. 2015 Nov 2;125(11):4008–10.
Stegbauer, Johannes, and Thomas M. Coffman. “Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.J Clin Invest, vol. 125, no. 11, Nov. 2015, pp. 4008–10. Pubmed, doi:10.1172/JCI84753.
Stegbauer J, Coffman TM. Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin. J Clin Invest. 2015 Nov 2;125(11):4008–4010.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

November 2, 2015

Volume

125

Issue

11

Start / End Page

4008 / 4010

Location

United States

Related Subject Headings

  • Sulfonamides
  • Sodium Chloride, Dietary
  • Pyrazoles
  • Male
  • Macrophages, Peritoneal
  • Immunology
  • Hypertension
  • Female
  • Dinoprostone
  • Cyclooxygenase 2 Inhibitors