Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.
Journal Article
The relationship between dietary salt intake and the associated risk of hypertension and cardiovascular disease is an important public health concern. In this issue of the JCI, a study by Zhang and associates shows that consumption of a high-sodium diet induces expression of cyclooxygenase-2 (COX-2) in macrophages, resulting in enhanced levels of prostaglandin E2 (PGE2), autocrine activation of the macrophage E-prostanoid 4 (EP4) receptor, and subsequent triggering of parallel pathways in the kidney and in skin that help dispose of excess sodium. The authors found that blockade or genetic elimination of the COX-2/PGE2/EP4 receptor pathway in hematopoietic cells causes salt-sensitive hypertension in mice. These studies illuminate an unexpected central role for the macrophage in coordinating homeostatic responses to dietary salt intake and suggest a complex pathophysiology for hypertension associated with NSAID use.
Full Text
Duke Authors
Cited Authors
- Stegbauer, J; Coffman, TM
Published Date
- November 2, 2015
Published In
Volume / Issue
- 125 / 11
Start / End Page
- 4008 - 4010
PubMed ID
- 26495835
Pubmed Central ID
- 26495835
Electronic International Standard Serial Number (EISSN)
- 1558-8238
Digital Object Identifier (DOI)
- 10.1172/JCI84753
Language
- eng
Conference Location
- United States