Dengue virus-induced autophagy regulates lipid metabolism.

Published

Journal Article

Autophagy influences numerous cellular processes, including innate and adaptive immunity against intracellular pathogens. However, some viruses, including dengue virus (DENV), usurp autophagy to enhance their replication. The mechanism for a positive role of autophagy in DENV infection is unclear. We present data that DENV induction of autophagy regulates cellular lipid metabolism. DENV infection leads to an autophagy-dependent processing of lipid droplets and triglycerides to release free fatty acids. This results in an increase in cellular β-oxidation, which generates ATP. These processes are required for efficient DENV replication. Importantly, exogenous fatty acids can supplant the requirement of autophagy in DENV replication. These results define a role for autophagy in DENV infection and provide a mechanism by which viruses can alter cellular lipid metabolism to promote their replication.

Full Text

Duke Authors

Cited Authors

  • Heaton, NS; Randall, G

Published Date

  • November 18, 2010

Published In

Volume / Issue

  • 8 / 5

Start / End Page

  • 422 - 432

PubMed ID

  • 21075353

Pubmed Central ID

  • 21075353

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2010.10.006

Language

  • eng

Conference Location

  • United States