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Dengue virus and autophagy.

Publication ,  Journal Article
Heaton, NS; Randall, G
Published in: Viruses
August 2011

Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER) cisternae invaginations and not on classical autophagosomes. Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. DENV-induced autophagosomes deplete cellular triglycerides that are stored in lipid droplets, leading to increased β-oxidation and energy production. This is the first example of a virus triggering autophagy to modulate cellular physiology. In this review, we summarize these data and discuss new questions and implications for autophagy during DENV replication.

Duke Scholars

Published In

Viruses

DOI

EISSN

1999-4915

Publication Date

August 2011

Volume

3

Issue

8

Start / End Page

1332 / 1341

Location

Switzerland

Related Subject Headings

  • Virus Replication
  • Viral Proteins
  • RNA, Viral
  • Phagosomes
  • Oxidation-Reduction
  • Lipid Metabolism
  • Humans
  • Hepatocytes
  • Endoplasmic Reticulum
  • Dengue Virus
 

Citation

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Heaton, N. S., & Randall, G. (2011). Dengue virus and autophagy. Viruses, 3(8), 1332–1341. https://doi.org/10.3390/v3081332
Heaton, Nicholas S., and Glenn Randall. “Dengue virus and autophagy.Viruses 3, no. 8 (August 2011): 1332–41. https://doi.org/10.3390/v3081332.
Heaton NS, Randall G. Dengue virus and autophagy. Viruses. 2011 Aug;3(8):1332–41.
Heaton, Nicholas S., and Glenn Randall. “Dengue virus and autophagy.Viruses, vol. 3, no. 8, Aug. 2011, pp. 1332–41. Pubmed, doi:10.3390/v3081332.
Heaton NS, Randall G. Dengue virus and autophagy. Viruses. 2011 Aug;3(8):1332–1341.

Published In

Viruses

DOI

EISSN

1999-4915

Publication Date

August 2011

Volume

3

Issue

8

Start / End Page

1332 / 1341

Location

Switzerland

Related Subject Headings

  • Virus Replication
  • Viral Proteins
  • RNA, Viral
  • Phagosomes
  • Oxidation-Reduction
  • Lipid Metabolism
  • Humans
  • Hepatocytes
  • Endoplasmic Reticulum
  • Dengue Virus