Long-term survival of influenza virus infected club cells drives immunopathology.

Journal Article

Respiratory infection of influenza A virus (IAV) is frequently characterized by extensive immunopathology and proinflammatory signaling that can persist after virus clearance. In this report, we identify cells that become infected, but survive, acute influenza virus infection. We demonstrate that these cells, known as club cells, elicit a robust transcriptional response to virus infection, show increased interferon stimulation, and induce high levels of proinflammatory cytokines after successful viral clearance. Specific depletion of these surviving cells leads to a reduction in lung tissue damage associated with IAV infection. We propose a model in which infected, surviving club cells establish a proinflammatory environment aimed at controlling virus levels, but at the same time contribute to lung pathology.

Full Text

Duke Authors

Cited Authors

  • Heaton, NS; Langlois, RA; Sachs, D; Lim, JK; Palese, P; tenOever, BR

Published Date

  • August 18, 2014

Published In

Volume / Issue

  • 211 / 9

Start / End Page

  • 1707 - 1714

PubMed ID

  • 25135297

Electronic International Standard Serial Number (EISSN)

  • 1540-9538

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20140488

Language

  • eng