Long-term survival of influenza virus infected club cells drives immunopathology.
Journal Article (Journal Article)
Respiratory infection of influenza A virus (IAV) is frequently characterized by extensive immunopathology and proinflammatory signaling that can persist after virus clearance. In this report, we identify cells that become infected, but survive, acute influenza virus infection. We demonstrate that these cells, known as club cells, elicit a robust transcriptional response to virus infection, show increased interferon stimulation, and induce high levels of proinflammatory cytokines after successful viral clearance. Specific depletion of these surviving cells leads to a reduction in lung tissue damage associated with IAV infection. We propose a model in which infected, surviving club cells establish a proinflammatory environment aimed at controlling virus levels, but at the same time contribute to lung pathology.
Full Text
Duke Authors
Cited Authors
- Heaton, NS; Langlois, RA; Sachs, D; Lim, JK; Palese, P; tenOever, BR
Published Date
- August 25, 2014
Published In
Volume / Issue
- 211 / 9
Start / End Page
- 1707 - 1714
PubMed ID
- 25135297
Pubmed Central ID
- PMC4144728
Electronic International Standard Serial Number (EISSN)
- 1540-9538
Digital Object Identifier (DOI)
- 10.1084/jem.20140488
Language
- eng
Conference Location
- United States