Neuropsychological profile in adult schizophrenia measured with the CMINDS.

Published

Journal Article

Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS(®)). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=-1.14), Attention/Vigilance (d=-1.04), Working Memory (d=-1.03), Verbal Learning (d=-1.02), Visual Learning (d=-0.91), and Reasoning/Problem Solving (d=-0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.

Full Text

Duke Authors

Cited Authors

  • van Erp, TGM; Preda, A; Turner, JA; Callahan, S; Calhoun, VD; Bustillo, JR; Lim, KO; Mueller, B; Brown, GG; Vaidya, JG; McEwen, S; Belger, A; Voyvodic, J; Mathalon, DH; Nguyen, D; Ford, JM; Potkin, SG; FBIRN,

Published Date

  • December 2015

Published In

Volume / Issue

  • 230 / 3

Start / End Page

  • 826 - 834

PubMed ID

  • 26586142

Pubmed Central ID

  • 26586142

Electronic International Standard Serial Number (EISSN)

  • 1872-7123

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/j.psychres.2015.10.028

Language

  • eng